Detailed information of TA system TA217866

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 3959717..3960252
• Replicon: chromosome
• Accession: NZ_CP083956
• Organism: Mesorhizobium sp. B1-1-8

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FJ974_RS19290
• Protein ID: WP_140538466.1
• Coordinates: 3959717..3959992 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FJ974_RS19295
• Protein ID: WP_140538467.1
• Coordinates: 3959992..3960252 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FJ974_RS19265 (FJ974_19265)	3955163..3956323	-	1161	WP_140538461.1	ABC transporter permease	-
FJ974_RS19270 (FJ974_19270)	3956362..3957228	-	867	WP_226891637.1	ABC transporter substrate-binding protein	-
FJ974_RS19275 (FJ974_19275)	3957434..3958654	-	1221	WP_140538463.1	MFS transporter	-
FJ974_RS19280 (FJ974_19280)	3958651..3959145	-	495	WP_140538464.1	transcription antitermination factor NusB	-
FJ974_RS19285 (FJ974_19285)	3959142..3959636	-	495	WP_140538465.1	6,7-dimethyl-8-ribityllumazine synthase	-
FJ974_RS19290 (FJ974_19290)	3959717..3959992	-	276	WP_140538466.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FJ974_RS19295 (FJ974_19295)	3959992..3960252	-	261	WP_140538467.1	ribbon-helix-helix domain-containing protein	Antitoxin
FJ974_RS19300 (FJ974_19300)	3960324..3960941	-	618	WP_140538468.1	riboflavin synthase	-
FJ974_RS19305 (FJ974_19305)	3960941..3962071	-	1131	WP_181177301.1	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	-
FJ974_RS19310 (FJ974_19310)	3962074..3962553	-	480	WP_140538469.1	transcriptional regulator NrdR	-
FJ974_RS19315 (FJ974_19315)	3962720..3963310	-	591	WP_140538513.1	hypothetical protein	-
FJ974_RS19320 (FJ974_19320)	3963390..3964703	-	1314	WP_140538470.1	serine hydroxymethyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-42)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10826.48 Da
• Isoelectric Point: 10.2941

>T217866 WP_140538466.1 NZ_CP083956:c3959992-3959717 [Mesorhizobium sp. B1-1-8]
MELNWTRKALSDLVRLHDFLAPVNSQAAARVVQSLAAAPKRLVEYPRIGERLEQYEPREVRRILVGNYEIRYEIRNSTIL
VLRLWHTREDR

Nucleotide

• Length: 276 bp

>T217866 NZ_CP114892:c2266936-2266529 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9595.05 Da
• Isoelectric Point: 5.6158

>AT217866 WP_140538467.1 NZ_CP083956:c3960252-3959992 [Mesorhizobium sp. B1-1-8]
MDTKVITAHVPLPLAEKVDQLAARLERPRGWIVKQALSAWVDLEEERHKLTLEALAEVDAGRIIDHQAVQAWADSLGTEK
PVPVPR

Nucleotide

• Length: 261 bp

>AT217866 NZ_CP114892:c2267183-2266917 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA