Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 2546767..2547434 Replicon chromosome
Accession NZ_CP083956
Organism Mesorhizobium sp. B1-1-8

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FJ974_RS12455 Protein ID WP_140535209.1
Coordinates 2547036..2547434 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FJ974_RS12450 Protein ID WP_140535207.1
Coordinates 2546767..2547036 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJ974_RS12425 (FJ974_12425) 2542162..2543142 + 981 WP_140535196.1 ABC transporter permease -
FJ974_RS12430 (FJ974_12430) 2543139..2544125 + 987 WP_140535198.1 ABC transporter permease -
FJ974_RS12435 (FJ974_12435) 2544170..2544673 + 504 WP_226891584.1 gluconokinase -
FJ974_RS12440 (FJ974_12440) 2544670..2545821 - 1152 WP_140535204.1 hypothetical protein -
FJ974_RS12445 (FJ974_12445) 2546004..2546453 - 450 WP_040984137.1 Rrf2 family transcriptional regulator -
FJ974_RS12450 (FJ974_12450) 2546767..2547036 + 270 WP_140535207.1 antitoxin Antitoxin
FJ974_RS12455 (FJ974_12455) 2547036..2547434 + 399 WP_140535209.1 type II toxin-antitoxin system VapC family toxin Toxin
FJ974_RS12460 (FJ974_12460) 2547444..2548484 - 1041 WP_140535212.1 sulfate/molybdate ABC transporter ATP-binding protein -
FJ974_RS12465 (FJ974_12465) 2548520..2549404 - 885 WP_140535215.1 sulfate ABC transporter permease subunit CysW -
FJ974_RS12470 (FJ974_12470) 2549397..2550248 - 852 WP_140535217.1 sulfate ABC transporter permease subunit CysT -
FJ974_RS12475 (FJ974_12475) 2550357..2551385 - 1029 WP_140535220.1 sulfate ABC transporter substrate-binding protein -
FJ974_RS12480 (FJ974_12480) 2551651..2551962 - 312 WP_181177200.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

SpoVT-AbrB domain

(16-54)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14021.20 Da        Isoelectric Point: 5.1869

>T217864 WP_140535209.1 NZ_CP083956:2547036-2547434 [Mesorhizobium sp. B1-1-8]
MRFMLDTNIISDIIRNPAGKAAGAVAREGDSAVCTSIVVASELRYGCARKGSAKLLAKVEELLAEVPVLPLDVPSDAKYG
ALRADLEASGQIIGHNDLFIAAHACTLGVTLVTANIGEFSRIKDLKVENWLE

Download         Length: 399 bp

>T217864 NZ_CP114892:1996344-1996673 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10083.63 Da        Isoelectric Point: 5.7252

>AT217864 WP_140535207.1 NZ_CP083956:2546767-2547036 [Mesorhizobium sp. B1-1-8]
MPQRHHSTPPKEAKLFRNNRSQAVRIPVEFELPGDKVLISRDGERLIIGPVRKPGIVALLAQWAKEPPLGPEEDFPEIDD
VPIKPEDIF

Download         Length: 270 bp

>AT217864 NZ_CP114892:1996006-1996323 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References