Detailed information of TA system TA217860

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yafQ-relB/YafQ-RelB
• Location: 4745322..4745853
• Replicon: chromosome
• Accession: NZ_CP083954
• Organism: Mesorhizobium sp. B2-1-1

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: -
• Locus tag: FJ972_RS23335
• Protein ID: WP_140520873.1
• Coordinates: 4745581..4745853 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FJ972_RS23330
• Protein ID: WP_140520872.1
• Coordinates: 4745322..4745579 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FJ972_RS23320 (FJ972_23320)	4742140..4743105	+	966	WP_140497839.1	sugar-binding transcriptional regulator	-
FJ972_RS23325 (FJ972_23325)	4743185..4745239	+	2055	WP_140520871.1	bifunctional aldolase/short-chain dehydrogenase	-
FJ972_RS23330 (FJ972_23330)	4745322..4745579	+	258	WP_140520872.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FJ972_RS23335 (FJ972_23335)	4745581..4745853	+	273	WP_140520873.1	type II toxin-antitoxin system YafQ family toxin	Toxin
FJ972_RS23340 (FJ972_23340)	4745928..4746980	-	1053	WP_140520874.1	substrate-binding domain-containing protein	-
FJ972_RS23345 (FJ972_23345)	4747021..4748016	-	996	WP_140520875.1	ABC transporter permease	-
FJ972_RS23350 (FJ972_23350)	4748109..4749620	-	1512	WP_140520876.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-84)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10637.23 Da
• Isoelectric Point: 8.4770

>T217860 WP_140520873.1 NZ_CP083954:4745581-4745853 [Mesorhizobium sp. B2-1-1]
MPTPVHSGQFRRDVKRMEKRGKDLAKLRELLGLLIAGLELPARYKDHPLKGDWKDYRDAHVEPDWLLIYRIADDELRLAR
TGFYSDLFNE

Nucleotide

• Length: 273 bp

>T217860 NZ_CP114892:1295705-1296079 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9103.55 Da
• Isoelectric Point: 8.6845

>AT217860 WP_140520872.1 NZ_CP083954:4745322-4745579 [Mesorhizobium sp. B2-1-1]
MATDTVVRARIDTATKDQATEALAAMGLSVSDAIRLLLVRVAADKEFPFPVKVPNATTQKAIAELEKGKGKRFASADELF
KDLGI

Nucleotide

• Length: 258 bp

>AT217860 NZ_CP114892:1295248-1295616 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA