Detailed information of TA system TA217859

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 4141718..4142316
• Replicon: chromosome
• Accession: NZ_CP083954
• Organism: Mesorhizobium sp. B2-1-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FJ972_RS20410
• Protein ID: WP_140494162.1
• Coordinates: 4141939..4142316 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: X6GS22
• Locus tag: FJ972_RS20405
• Protein ID: WP_023813589.1
• Coordinates: 4141718..4141942 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FJ972_RS20375 (FJ972_20375)	4136771..4137604	+	834	WP_140494152.1	zinc ABC transporter ATP-binding protein AztA	-
FJ972_RS20380 (FJ972_20380)	4137604..4138479	+	876	WP_140515812.1	zinc ABC transporter permease AztB	-
FJ972_RS20385 (FJ972_20385)	4138508..4139449	+	942	WP_140494154.1	zinc ABC transporter substrate-binding protein AztC	-
FJ972_RS20390 (FJ972_20390)	4139594..4139932	+	339	WP_140494156.1	TIGR01244 family sulfur transferase	-
FJ972_RS20395 (FJ972_20395)	4139929..4140396	-	468	WP_140494158.1	Lrp/AsnC family transcriptional regulator	-
FJ972_RS20400 (FJ972_20400)	4140535..4141647	+	1113	WP_140521713.1	4-hydroxyphenylpyruvate dioxygenase	-
FJ972_RS20405 (FJ972_20405)	4141718..4141942	+	225	WP_023813589.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FJ972_RS20410 (FJ972_20410)	4141939..4142316	+	378	WP_140494162.1	type II toxin-antitoxin system VapC family toxin	Toxin
FJ972_RS20415 (FJ972_20415)	4142326..4142862	-	537	WP_140494164.1	DinB family protein	-
FJ972_RS20420 (FJ972_20420)	4142882..4143895	-	1014	WP_140521711.1	fumarylacetoacetate hydrolase family protein	-
FJ972_RS20425 (FJ972_20425)	4144014..4145327	-	1314	WP_140521709.1	homogentisate 1,2-dioxygenase	-
FJ972_RS20430 (FJ972_20430)	4145427..4145870	+	444	WP_140521707.1	MarR family transcriptional regulator	-
FJ972_RS20435 (FJ972_20435)	4146029..4146667	+	639	WP_140521705.1	lysophospholipid acyltransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-121)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-42)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14027.27 Da
• Isoelectric Point: 7.1421

>T217859 WP_140494162.1 NZ_CP083954:4141939-4142316 [Mesorhizobium sp. B2-1-1]
MMIGPFLADTHIILWSISDDRRLSKHYRAILASEAVVFASAASVWEIAIKRSIRKLDAPDDLPTLLPRMQFQPLAVTFQH
ANAVAGLPHHHGDPFDRLLIAQAQMDKLTIMTSDPHFARYDVALT

Nucleotide

• Length: 378 bp

>T217859 NZ_CP114892:c1142167-1142064 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8038.26 Da
• Isoelectric Point: 4.7954

>AT217859 WP_023813589.1 NZ_CP083954:4141718-4141942 [Mesorhizobium sp. B2-1-1]
MNVSIAEAKAKLSELVSRAEAGEEIVLTRHGKVAARIVPPAAAEPLPRIGALKGKIWIADDFDELGPEWDEYVK

Nucleotide

• Length: 225 bp

>AT217859 NZ_CP114892:1142026-1142297 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Antitoxin

• AlphaFold DB: X6GS22