Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 3903056..3903467 Replicon chromosome
Accession NZ_CP083954
Organism Mesorhizobium sp. B2-1-1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FJ972_RS19195 Protein ID WP_140517667.1
Coordinates 3903056..3903256 (+) Length 67 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FJ972_RS19200 Protein ID WP_140517668.1
Coordinates 3903261..3903467 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJ972_RS19185 (FJ972_19185) 3898304..3898615 + 312 WP_140493741.1 PilZ domain-containing protein -
FJ972_RS19190 (FJ972_19190) 3899282..3903049 + 3768 WP_140522081.1 vitamin B12-dependent ribonucleotide reductase -
FJ972_RS19195 (FJ972_19195) 3903056..3903256 + 201 WP_140517667.1 type II toxin-antitoxin system HicA family toxin Toxin
FJ972_RS19200 (FJ972_19200) 3903261..3903467 + 207 WP_140517668.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FJ972_RS19205 (FJ972_19205) 3903518..3904144 - 627 WP_140517669.1 hypothetical protein -
FJ972_RS19210 (FJ972_19210) 3904137..3904658 - 522 WP_140517670.1 hypothetical protein -
FJ972_RS19215 (FJ972_19215) 3904865..3905203 + 339 WP_224519152.1 hypothetical protein -
FJ972_RS19220 (FJ972_19220) 3905214..3906188 - 975 WP_226880337.1 DUF3592 domain-containing protein -
FJ972_RS19225 (FJ972_19225) 3906362..3907444 - 1083 WP_140517671.1 GH25 family lysozyme -
FJ972_RS19230 (FJ972_19230) 3907616..3908401 - 786 WP_140522079.1 phosphodiester glycosidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(8-64)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-66)


Sequences

Toxin        


Download         Length: 67 a.a.        Molecular weight: 7330.53 Da        Isoelectric Point: 10.7459

>T217858 WP_140517667.1 NZ_CP083954:3903056-3903256 [Mesorhizobium sp. B2-1-1]
MPPRLTVREVIRLLETDGWYLVATKGSHRQYKHKIKAGRVTVAGKSSEEVAPGTLNSILKQSGLKE

Download         Length: 201 bp

>T217858 NZ_CP114892:c863643-863356 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7338.24 Da        Isoelectric Point: 3.9940

>AT217858 WP_140517668.1 NZ_CP083954:3903261-3903467 [Mesorhizobium sp. B2-1-1]
MRYAVVIEKAGDNFSAYVPDLPGCIATGATVPEVETEIRDAIRFHIEGLRADGLDVPESVSLAEYVEA

Download         Length: 207 bp

>AT217858 NZ_CP114892:c863882-863643 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References