Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) brnT-AbkA/BrnT-BrnA
Location 1166527..1167082 Replicon chromosome
Accession NZ_CP083954
Organism Mesorhizobium sp. B2-1-1

Toxin (Protein)


Gene name brnT Uniprot ID -
Locus tag FJ972_RS05605 Protein ID WP_140525035.1
Coordinates 1166527..1166814 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name AbkA Uniprot ID -
Locus tag FJ972_RS05610 Protein ID WP_140525036.1
Coordinates 1166795..1167082 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJ972_RS05580 (FJ972_05580) 1162886..1163725 - 840 WP_140493116.1 MoxR family ATPase -
FJ972_RS05590 (FJ972_05590) 1164135..1164722 + 588 WP_140525033.1 5-formyltetrahydrofolate cyclo-ligase -
FJ972_RS05595 (FJ972_05595) 1164784..1165608 + 825 WP_140493122.1 YmdB family metallophosphoesterase -
FJ972_RS05600 (FJ972_05600) 1165679..1166446 + 768 WP_140525034.1 TerC family protein -
FJ972_RS05605 (FJ972_05605) 1166527..1166814 + 288 WP_140525035.1 BrnT family toxin Toxin
FJ972_RS05610 (FJ972_05610) 1166795..1167082 + 288 WP_140525036.1 BrnA antitoxin family protein Antitoxin
FJ972_RS05615 (FJ972_05615) 1167089..1167556 - 468 WP_140525037.1 SRPBCC family protein -
FJ972_RS05620 (FJ972_05620) 1167775..1168143 - 369 WP_140525079.1 VOC family protein -
FJ972_RS05625 (FJ972_05625) 1168182..1168664 - 483 WP_140493137.1 SRPBCC domain-containing protein -
FJ972_RS05630 (FJ972_05630) 1168716..1169039 + 324 WP_140525038.1 helix-turn-helix domain-containing protein -
FJ972_RS05635 (FJ972_05635) 1169251..1170000 + 750 WP_140525039.1 YebC/PmpR family DNA-binding transcriptional regulator -
FJ972_RS05640 (FJ972_05640) 1170013..1170309 + 297 WP_140493146.1 SelT/SelW/SelH family protein -
FJ972_RS05645 (FJ972_05645) 1170331..1170492 - 162 WP_181165385.1 hypothetical protein -
FJ972_RS05650 (FJ972_05650) 1170556..1171035 - 480 WP_181170859.1 DUF1772 domain-containing protein -
FJ972_RS05655 (FJ972_05655) 1171257..1171892 + 636 WP_140517544.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-86)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(29-86)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11135.65 Da        Isoelectric Point: 6.7300

>T217857 WP_140525035.1 NZ_CP083954:1166527-1166814 [Mesorhizobium sp. B2-1-1]
MRFEWDAERARRKLAKLGIGFDLAQKVFDDPLYLIVPDRFEDGEQRWHAIGTIDAVVVMLVVHTYPDREDEGRVRIVGAR
KATAHERRRYEQEGP

Download         Length: 288 bp

>T217857 NZ_CP114892:c810186-808864 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10992.44 Da        Isoelectric Point: 9.6565

>AT217857 WP_140525036.1 NZ_CP083954:1166795-1167082 [Mesorhizobium sp. B2-1-1]
MSKKDLSQDQRNQLAKLAGLPDSEINTSDIPEVPAENWIHARRGHLYRPLKQPVTIRLDTDVLSWFKEHVGGGGYQTEIN
RVLRHHVIEQEKRKT

Download         Length: 288 bp

>AT217857 NZ_CP114892:c810452-810186 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References