Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4524766..4525301 Replicon chromosome
Accession NZ_CP083952
Organism Mesorhizobium sp. B2-1-8

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FJ970_RS22270 Protein ID WP_140755388.1
Coordinates 4524766..4525041 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FJ970_RS22275 Protein ID WP_140755390.1
Coordinates 4525041..4525301 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJ970_RS22245 (FJ970_22245) 4520767..4521678 - 912 WP_140755380.1 ABC transporter substrate-binding protein -
FJ970_RS22250 (FJ970_22250) 4521897..4522469 + 573 WP_140755382.1 NADPH-dependent FMN reductase -
FJ970_RS22255 (FJ970_22255) 4522484..4523698 - 1215 WP_140755384.1 MFS transporter -
FJ970_RS22260 (FJ970_22260) 4523695..4524195 - 501 WP_015318243.1 transcription antitermination factor NusB -
FJ970_RS22265 (FJ970_22265) 4524192..4524686 - 495 WP_140755386.1 6,7-dimethyl-8-ribityllumazine synthase -
FJ970_RS22270 (FJ970_22270) 4524766..4525041 - 276 WP_140755388.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FJ970_RS22275 (FJ970_22275) 4525041..4525301 - 261 WP_140755390.1 ribbon-helix-helix domain-containing protein Antitoxin
FJ970_RS22280 (FJ970_22280) 4525372..4525989 - 618 WP_140755392.1 riboflavin synthase -
FJ970_RS22285 (FJ970_22285) 4525996..4527132 - 1137 WP_140755394.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
FJ970_RS22290 (FJ970_22290) 4527135..4527614 - 480 WP_015318247.1 transcriptional regulator NrdR -
FJ970_RS22295 (FJ970_22295) 4527813..4528391 - 579 WP_181178296.1 hypothetical protein -
FJ970_RS22300 (FJ970_22300) 4528509..4529822 - 1314 WP_140755398.1 serine hydroxymethyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10550.18 Da        Isoelectric Point: 8.6217

>T217855 WP_140755388.1 NZ_CP083952:c4525041-4524766 [Mesorhizobium sp. B2-1-8]
MELKWTSKALSDLVRLHDFLAAVNNQAAARAVQSLVAAPARLIENPRIGEKLEEFEPREVRRILVGNYEIRYEIANATIL
LLRLWHTREDR

Download         Length: 276 bp

>T217855 NZ_CP114892:c631707-631513 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9642.11 Da        Isoelectric Point: 5.7066

>AT217855 WP_140755390.1 NZ_CP083952:c4525301-4525041 [Mesorhizobium sp. B2-1-8]
MDTKVITAHVPLPLAEKVDQLAARLERPRGWIVKQALSAWVDLEEERRRLTLEALADVDAGRVIDHQAVQAWAESLGTEK
PLPVPR

Download         Length: 261 bp

>AT217855 NZ_CP114892:631336-631514 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References