Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3229306..3229982 Replicon chromosome
Accession NZ_CP083952
Organism Mesorhizobium sp. B2-1-8

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FJ970_RS15825 Protein ID WP_140758059.1
Coordinates 3229557..3229982 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FJ970_RS15820 Protein ID WP_140758060.1
Coordinates 3229306..3229560 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJ970_RS15795 (FJ970_15795) 3224658..3225311 + 654 WP_140758065.1 TetR/AcrR family transcriptional regulator -
FJ970_RS15800 (FJ970_15800) 3225446..3226465 + 1020 WP_140758064.1 ketol-acid reductoisomerase -
FJ970_RS15805 (FJ970_15805) 3226541..3227122 - 582 WP_140758063.1 BA14K family protein -
FJ970_RS15810 (FJ970_15810) 3227285..3228412 + 1128 WP_140758062.1 endonuclease -
FJ970_RS15815 (FJ970_15815) 3228449..3229165 + 717 WP_140758061.1 hypothetical protein -
FJ970_RS15820 (FJ970_15820) 3229306..3229560 + 255 WP_140758060.1 Arc family DNA-binding protein Antitoxin
FJ970_RS15825 (FJ970_15825) 3229557..3229982 + 426 WP_140758059.1 type II toxin-antitoxin system VapC family toxin Toxin
FJ970_RS15830 (FJ970_15830) 3230047..3231264 - 1218 WP_140758058.1 ABC transporter permease -
FJ970_RS15835 (FJ970_15835) 3231267..3231968 - 702 WP_140758057.1 ABC transporter ATP-binding protein -
FJ970_RS15840 (FJ970_15840) 3231973..3233259 - 1287 WP_140758056.1 efflux RND transporter periplasmic adaptor subunit -
FJ970_RS15845 (FJ970_15845) 3233361..3234269 + 909 WP_140758055.1 PhzF family phenazine biosynthesis protein -
FJ970_RS15855 (FJ970_15855) 3234569..3234880 - 312 WP_140758054.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 14996.25 Da        Isoelectric Point: 5.0900

>T217854 WP_140758059.1 NZ_CP083952:3229557-3229982 [Mesorhizobium sp. B2-1-8]
MILIDTNVISEPWRPAPDPRVIGWIDAQAVETLYLSAVTVAELRFGIAAMPAGKRRTILQDRLEQDALPLFAGRILPFDL
DASRAYANLMVQARAAGKAIGNADGYIAATAVAHGLTIATRDTGPFAAAGLNTVNPWEAAI

Download         Length: 426 bp

>T217854 NZ_CP114892:c440169-440062 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9114.42 Da        Isoelectric Point: 8.9339

>AT217854 WP_140758060.1 NZ_CP083952:3229306-3229560 [Mesorhizobium sp. B2-1-8]
MSAVTIRNLPEETLRALKVRAAHHGRSTEAEMREILETAVRPPSRVKLGSLLAAIGREAGLSDGDVDALQQLRDKTPGGP
VRFE

Download         Length: 255 bp

>AT217854 NZ_CP114892:440216-440282 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References