Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2718244..2718839 Replicon chromosome
Accession NZ_CP083952
Organism Mesorhizobium sp. B2-1-8

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FJ970_RS13320 Protein ID WP_140763548.1
Coordinates 2718651..2718839 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FJ970_RS13315 Protein ID WP_140763551.1
Coordinates 2718244..2718645 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJ970_RS13285 (FJ970_13285) 2713397..2713693 + 297 WP_140763566.1 DUF1236 domain-containing protein -
FJ970_RS13290 (FJ970_13290) 2713966..2714445 - 480 WP_140763563.1 DUF2127 domain-containing protein -
FJ970_RS13295 (FJ970_13295) 2714493..2715034 + 542 Protein_2635 phosphatase PAP2 family protein -
FJ970_RS13300 (FJ970_13300) 2715209..2716057 - 849 WP_181178773.1 helix-turn-helix transcriptional regulator -
FJ970_RS13305 (FJ970_13305) 2716163..2717047 + 885 WP_140763557.1 SDR family oxidoreductase -
FJ970_RS13310 (FJ970_13310) 2717368..2718066 - 699 WP_140763554.1 RibD family protein -
FJ970_RS13315 (FJ970_13315) 2718244..2718645 - 402 WP_140763551.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FJ970_RS13320 (FJ970_13320) 2718651..2718839 - 189 WP_140763548.1 type II toxin-antitoxin system HicA family toxin Toxin
FJ970_RS13325 (FJ970_13325) 2719158..2720105 + 948 WP_140763545.1 substrate-binding domain-containing protein -
FJ970_RS13330 (FJ970_13330) 2720349..2721950 + 1602 WP_140759858.1 sugar ABC transporter ATP-binding protein -
FJ970_RS13335 (FJ970_13335) 2721947..2722963 + 1017 WP_140759855.1 ABC transporter permease -
FJ970_RS13340 (FJ970_13340) 2723065..2723427 - 363 WP_140759852.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7060.21 Da        Isoelectric Point: 11.3076

>T217851 WP_140763548.1 NZ_CP083952:c2718839-2718651 [Mesorhizobium sp. B2-1-8]
MTSAEIIRLLEADGWFEVARKGSHAQFKHRDKPGRVTVPHPKRDIPIGTLRSIEKQSGLKLR

Download         Length: 189 bp

>T217851 NZ_CP114891:4238385-4238492 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14141.93 Da        Isoelectric Point: 4.2919

>AT217851 WP_140763551.1 NZ_CP083952:c2718645-2718244 [Mesorhizobium sp. B2-1-8]
MKQYIGLIHKDADSDFGVSFPDFPGVITAGKDLDDARSMAEEALALHIEGLVEDGDAIPEPSSLETVMTDADNRDGVAIL
VAARTGARKAVRINVTLPDDVLQRIDAFAEAHGYTRSGFLAKAAEKVMALEAA

Download         Length: 402 bp

>AT217851 NZ_CP114891:c4238337-4238271 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References