Detailed information of TA system TA217846

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 4858421..4859015
• Replicon: chromosome
• Accession: NZ_CP083951
• Organism: Mesorhizobium sp. B2-8-5

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FJ430_RS23770
• Protein ID: WP_140710766.1
• Coordinates: 4858421..4858609 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FJ430_RS23775
• Protein ID: WP_140710768.1
• Coordinates: 4858614..4859015 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FJ430_RS23750 (FJ430_23750)	4854715..4855308	-	594	WP_140710760.1	hypothetical protein	-
FJ430_RS23755 (FJ430_23755)	4855534..4856523	-	990	WP_140710762.1	Coat protein	-
FJ430_RS23760 (FJ430_23760)	4856567..4857472	-	906	WP_140710800.1	hypothetical protein	-
FJ430_RS23765 (FJ430_23765)	4857672..4858244	-	573	WP_140710764.1	hypothetical protein	-
FJ430_RS23770 (FJ430_23770)	4858421..4858609	+	189	WP_140710766.1	type II toxin-antitoxin system HicA family toxin	Toxin
FJ430_RS23775 (FJ430_23775)	4858614..4859015	+	402	WP_140710768.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FJ430_RS23780 (FJ430_23780)	4859219..4859536	+	318	WP_140536753.1	YMGG-like glycine zipper-containing protein	-
FJ430_RS23785 (FJ430_23785)	4859574..4860065	-	492	WP_140710770.1	hypothetical protein	-
FJ430_RS23790 (FJ430_23790)	4860052..4860381	-	330	WP_181175585.1	STAS-like domain-containing protein	-
FJ430_RS23795 (FJ430_23795)	4860368..4861078	-	711	WP_181175586.1	hypothetical protein	-
FJ430_RS23800 (FJ430_23800)	4861723..4862142	+	420	WP_140710774.1	hypothetical protein	-
FJ430_RS23805 (FJ430_23805)	4862461..4862652	-	192	WP_140710776.1	hypothetical protein	-
FJ430_RS23810 (FJ430_23810)	4862655..4863044	-	390	WP_140659358.1	SMI1/KNR4 family protein	-
FJ430_RS23815 (FJ430_23815)	4863217..4863693	-	477	WP_140659359.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4842431..4859015	16584

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6975.18 Da
• Isoelectric Point: 11.2699

>T217846 WP_140710766.1 NZ_CP083951:4858421-4858609 [Mesorhizobium sp. B2-8-5]
MKSADVIDKLLADGWFEVARKGSHAQFKHRTKPGRVTVPHPKRDIPIGTLKSIEKQSGLKLR

Nucleotide

• Length: 189 bp

>T217846 NZ_CP114891:c3120358-3119960 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14329.93 Da
• Isoelectric Point: 4.2266

>AT217846 WP_140710768.1 NZ_CP083951:4858614-4859015 [Mesorhizobium sp. B2-8-5]
MRHYIGLIHKDADSDFGVSFPDFPGVVTAGTSLDEARTLAEEALAFHVDGLVEDGEAIPEPSSLEDVMADEDNRAGVAIL
VTLKTEAAKVVRVNVTIPEDVLGEIDRYAERHGYSRSGFLTAAAREAMRNEAA

Nucleotide

• Length: 402 bp

>AT217846 NZ_CP114891:c3120654-3120361 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA