Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 5491842..5492644 Replicon chromosome
Accession NZ_CP083950
Organism Mesorhizobium sp. B4-1-4

Toxin (Protein)


Gene name TacT3 Uniprot ID -
Locus tag FJW03_RS26450 Protein ID WP_140767157.1
Coordinates 5491842..5492369 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID -
Locus tag FJW03_RS26455 Protein ID WP_140606738.1
Coordinates 5492366..5492644 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJW03_RS26435 (FJW03_26435) 5487742..5489127 - 1386 WP_181173371.1 glutamine synthetase family protein -
FJW03_RS26440 (FJW03_26440) 5489160..5490542 - 1383 WP_140767159.1 aspartate aminotransferase family protein -
FJW03_RS26445 (FJW03_26445) 5490781..5491755 - 975 WP_140767158.1 WD40 repeat domain-containing protein -
FJW03_RS26450 (FJW03_26450) 5491842..5492369 - 528 WP_140767157.1 GNAT family N-acetyltransferase Toxin
FJW03_RS26455 (FJW03_26455) 5492366..5492644 - 279 WP_140606738.1 DUF1778 domain-containing protein Antitoxin
FJW03_RS26460 (FJW03_26460) 5492727..5493791 - 1065 WP_140767156.1 GTP-binding protein -
FJW03_RS26465 (FJW03_26465) 5494213..5494683 + 471 WP_140606740.1 MarR family winged helix-turn-helix transcriptional regulator -
FJW03_RS26470 (FJW03_26470) 5494701..5495570 - 870 WP_140767155.1 AraC family transcriptional regulator -
FJW03_RS26475 (FJW03_26475) 5495624..5496031 + 408 WP_140767154.1 DUF2000 family protein -
FJW03_RS26480 (FJW03_26480) 5496235..5497119 + 885 WP_181168761.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(11-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 18956.65 Da        Isoelectric Point: 8.7422

>T217843 WP_140767157.1 NZ_CP083950:c5492369-5491842 [Mesorhizobium sp. B4-1-4]
VTLPPWHEEPIAKGHDRASFDCGDRQMNDFLRRFARQSHDQNAAKTFCAIDDTASERILGFYTIAPSAVAHETVPETMTK
GLARHEVSGFKLARLATDRTVAGHGLGGQLLAAAALRCLRLAGEGGGILLIIDAKNERAARWYASYGAERVQGRELTLVM
PLATFASGLRAKGLL

Download         Length: 528 bp

>T217843 NZ_CP114891:2146353-2146460 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10114.77 Da        Isoelectric Point: 10.0884

>AT217843 WP_140606738.1 NZ_CP083950:c5492644-5492366 [Mesorhizobium sp. B4-1-4]
MPRSADNKSERFQIRIPPAQKAMIARAAALSHKDMTDFILDKIVPEAQAVIEAAEVTTVSGRDFTRILNLLEHPPKPNAK
LRAAIATLPDTL

Download         Length: 279 bp

>AT217843 NZ_CP114891:c2146306-2146240 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References