Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2583209..2583879 Replicon chromosome
Accession NZ_CP083950
Organism Mesorhizobium sp. B4-1-4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FJW03_RS12475 Protein ID WP_181173325.1
Coordinates 2583209..2583610 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FJW03_RS12480 Protein ID WP_140766410.1
Coordinates 2583607..2583879 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJW03_RS12450 (FJW03_12450) 2579076..2579246 - 171 WP_181168847.1 hypothetical protein -
FJW03_RS12455 (FJW03_12455) 2579301..2580329 + 1029 WP_140766407.1 sulfate ABC transporter substrate-binding protein -
FJW03_RS12460 (FJW03_12460) 2580347..2581198 + 852 WP_140608974.1 sulfate ABC transporter permease subunit CysT -
FJW03_RS12465 (FJW03_12465) 2581191..2582075 + 885 WP_140766408.1 sulfate ABC transporter permease subunit CysW -
FJW03_RS12470 (FJW03_12470) 2582146..2583201 + 1056 WP_140766409.1 sulfate/molybdate ABC transporter ATP-binding protein -
FJW03_RS12475 (FJW03_12475) 2583209..2583610 - 402 WP_181173325.1 type II toxin-antitoxin system VapC family toxin Toxin
FJW03_RS12480 (FJW03_12480) 2583607..2583879 - 273 WP_140766410.1 antitoxin Antitoxin
FJW03_RS12485 (FJW03_12485) 2584102..2585088 + 987 WP_140766411.1 sulfate ABC transporter substrate-binding protein -
FJW03_RS12490 (FJW03_12490) 2585340..2585789 + 450 WP_023768256.1 Rrf2 family transcriptional regulator -
FJW03_RS12495 (FJW03_12495) 2585799..2586941 + 1143 WP_140766412.1 hypothetical protein -
FJW03_RS12500 (FJW03_12500) 2586936..2587484 - 549 WP_140608988.1 gluconokinase -
FJW03_RS12505 (FJW03_12505) 2587487..2588473 - 987 WP_140766413.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(17-55)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14047.39 Da        Isoelectric Point: 6.4514

>T217841 WP_181173325.1 NZ_CP083950:c2583610-2583209 [Mesorhizobium sp. B4-1-4]
MIRFMLDTNIISDMIRNPAGKAASTVLRVGDSAVCTSIVVASELRYGCARKGSAKLLKKVEELLAEIPVLPLDVPADAGY
GAIRAELEGLGQPIGHNDLFIAAHACALGITLVTANTGEFTRISGLKVENWLA

Download         Length: 402 bp

>T217841 NZ_CP114891:c1857722-1857546 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10296.70 Da        Isoelectric Point: 4.8723

>AT217841 WP_140766410.1 NZ_CP083950:c2583879-2583607 [Mesorhizobium sp. B4-1-4]
MPQHRQSTTRPKEAKLFRNNRSQAVRIPVEFELPGDRVLISREGDRLVIEPVRRPGLTALLAQWANELPLGPEDDFPEFD
DAPVKPEDIL

Download         Length: 273 bp

>AT217841 NZ_CP114891:c1857500-1857084 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References