Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/ParD(antitoxin)
Location 2504234..2505232 Replicon chromosome
Accession NC_008595
Organism Mycobacterium avium 104

Toxin (Protein)


Gene name pezT Uniprot ID X7VT18
Locus tag MAV_RS11770 Protein ID WP_003876749.1
Coordinates 2504654..2505232 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A049EEK5
Locus tag MAV_RS11765 Protein ID WP_009976725.1
Coordinates 2504234..2504623 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAV_RS11745 2499370..2500050 - 681 WP_023861532.1 hypothetical protein -
MAV_RS11750 2500129..2501646 + 1518 WP_011724808.1 carboxylesterase/lipase family protein -
MAV_RS11755 2501665..2503662 + 1998 WP_011724809.1 phosphotransferase -
MAV_RS11760 2503659..2504153 + 495 WP_010949355.1 gluconokinase -
MAV_RS11765 2504234..2504623 + 390 WP_009976725.1 hypothetical protein Antitoxin
MAV_RS11770 2504654..2505232 + 579 WP_003876749.1 zeta toxin family protein Toxin
MAV_RS11775 2505237..2506304 - 1068 WP_003876748.1 DoxX family membrane protein -
MAV_RS11780 2506415..2506975 + 561 WP_011724811.1 pyrazinamidase PncA -
MAV_RS11785 2506975..2507775 + 801 WP_011724812.1 nuclear transport factor 2 family protein -
MAV_RS11790 2507789..2508139 - 351 WP_011724813.1 DoxX family protein -
MAV_RS11795 2508308..2509240 + 933 WP_011724814.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(5-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21034.18 Da        Isoelectric Point: 10.6678

>T21784 WP_003876749.1 NC_008595:2504654-2505232 [Mycobacterium avium 104]
MERLDVVVGPNGAGKSTFIALTLAPLLPGSVVVNADEIARQRWPQDPASHAYDAAKVAADTRAKLIDLGRSFIAETVFSH
PSKLDLLHAARRAGFTVVLHVLLIPEDLAVERVRHRVRAGGHDVPETKIRERHRRLWTPVAEAMTLADLATGYDNSRLRG
PRVVARLSGGLTVGAVDWPAWAPETLRSRWPV

Download         Length: 579 bp

>T21784 NC_008595:2504654-2505232 [Mycobacterium avium 104]
ATGGAGCGACTCGACGTGGTGGTCGGGCCCAACGGCGCCGGCAAGTCGACGTTCATCGCGTTGACCCTGGCGCCGCTGCT
GCCGGGCAGCGTGGTGGTCAACGCCGACGAGATCGCGCGGCAGCGCTGGCCGCAGGATCCGGCGTCGCACGCCTACGACG
CCGCGAAGGTCGCCGCCGACACCCGGGCGAAGCTGATCGACCTGGGCCGGTCGTTCATCGCCGAGACCGTGTTCTCCCAC
CCGTCCAAGCTGGACCTGCTGCACGCCGCCCGCCGCGCCGGCTTCACCGTCGTGCTGCACGTGCTGCTCATCCCGGAAGA
CCTTGCCGTCGAACGGGTCCGGCACCGCGTGCGGGCCGGCGGCCATGACGTGCCGGAAACCAAGATCCGCGAGCGGCATC
GCCGGTTGTGGACTCCGGTCGCCGAGGCGATGACCCTGGCCGACCTGGCCACCGGCTACGACAACAGCCGGCTGCGCGGG
CCGCGTGTGGTGGCCCGGCTCAGCGGCGGGCTGACGGTCGGTGCCGTCGACTGGCCGGCGTGGGCACCCGAGACCTTGCG
GTCGCGTTGGCCGGTCTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13598.04 Da        Isoelectric Point: 5.6717

>AT21784 WP_009976725.1 NC_008595:2504234-2504623 [Mycobacterium avium 104]
MAEAVDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGRLSTAELTVEEGVVFNAEI
SAAIDESLARTNYGATLAGQGVTTVALNDDGEIVEHRPDGTAVVLAGRR

Download         Length: 390 bp

>AT21784 NC_008595:2504234-2504623 [Mycobacterium avium 104]
ATGGCCGAGGCCGTCGATCGGGTCACCCGGGTCGCGTCCGATCTGATGGACAGCGCGGCGGCCGAGGGCGCCCGTCAGAG
CCGCTCGGCCAAGCAGCAGCTCGACCACTGGGCGCGGGTCGGGCGTGCGGTGTCCAGCCAGCACACCGCGTCCCGGCGGC
GGGTCGAAGCCGCGCTGGCCGGCCGGCTGTCCACCGCCGAACTCACCGTCGAAGAGGGCGTGGTGTTCAACGCCGAGATC
TCGGCGGCCATCGACGAAAGCCTGGCGCGCACCAACTACGGGGCGACGCTGGCCGGGCAGGGTGTCACCACGGTGGCCCT
CAACGACGATGGCGAGATCGTCGAGCACCGGCCCGACGGCACCGCGGTGGTGCTGGCCGGCCGGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2W6B4

Antitoxin

Source ID Structure
AlphaFold DB A0A049EEK5

References