Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1333115..1333650 Replicon chromosome
Accession NZ_CP083950
Organism Mesorhizobium sp. B4-1-4

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FJW03_RS06290 Protein ID WP_140762820.1
Coordinates 1333375..1333650 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FJW03_RS06285 Protein ID WP_140692671.1
Coordinates 1333115..1333375 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJW03_RS06260 (FJW03_06260) 1328623..1329936 + 1314 WP_015318249.1 serine hydroxymethyltransferase -
FJW03_RS06265 (FJW03_06265) 1330016..1330594 + 579 WP_181165597.1 hypothetical protein -
FJW03_RS06270 (FJW03_06270) 1330799..1331278 + 480 WP_010915593.1 transcriptional regulator NrdR -
FJW03_RS06275 (FJW03_06275) 1331281..1332411 + 1131 WP_140762826.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
FJW03_RS06280 (FJW03_06280) 1332423..1333040 + 618 WP_140762823.1 riboflavin synthase -
FJW03_RS06285 (FJW03_06285) 1333115..1333375 + 261 WP_140692671.1 ribbon-helix-helix domain-containing protein Antitoxin
FJW03_RS06290 (FJW03_06290) 1333375..1333650 + 276 WP_140762820.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FJW03_RS06295 (FJW03_06295) 1333732..1334226 + 495 WP_140609994.1 6,7-dimethyl-8-ribityllumazine synthase -
FJW03_RS06300 (FJW03_06300) 1334223..1334723 + 501 WP_140609995.1 transcription antitermination factor NusB -
FJW03_RS06305 (FJW03_06305) 1334720..1335958 + 1239 WP_140762817.1 MFS transporter -
FJW03_RS06310 (FJW03_06310) 1336115..1337026 + 912 WP_140762813.1 ABC transporter substrate-binding protein -
FJW03_RS06315 (FJW03_06315) 1337239..1338402 + 1164 WP_140762810.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10548.12 Da        Isoelectric Point: 8.5620

>T217839 WP_140762820.1 NZ_CP083950:1333375-1333650 [Mesorhizobium sp. B4-1-4]
MELKWTSKALSDLVRLHDFLAPANGPAAARAVQSLAAAPARLVEYPRIGERLEEFEPREVRRILVGSYEIRYEIQSTTIF
VLRLWHTREDR

Download         Length: 276 bp

>T217839 NZ_CP114891:1722345-1722632 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9614.05 Da        Isoelectric Point: 5.1133

>AT217839 WP_140692671.1 NZ_CP083950:1333115-1333375 [Mesorhizobium sp. B4-1-4]
MDTKVITAHVPLPLAEKVDQLAARLERPRGWIVKQALSAWVDLEEERQRLTLEALADVDAGRVIDHQAVQAWAESLGTEK
PLPVPR

Download         Length: 261 bp

>AT217839 NZ_CP114891:1722106-1722345 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References