Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YoeB-RelB |
| Location | 36936..37446 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP083948 | ||
| Organism | Acinetobacter johnsonii strain CSUSB1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A3D2SPX3 |
| Locus tag | LCH18_RS17430 | Protein ID | WP_034617162.1 |
| Coordinates | 36936..37196 (-) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A3D2SPQ8 |
| Locus tag | LCH18_RS17435 | Protein ID | WP_034617158.1 |
| Coordinates | 37180..37446 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LCH18_RS17410 (LCH18_17410) | 32797..33309 | + | 513 | Protein_35 | ATP-dependent endonuclease | - |
| LCH18_RS17415 (LCH18_17415) | 33306..34964 | + | 1659 | WP_224469584.1 | ATP-dependent helicase | - |
| LCH18_RS17420 (LCH18_17420) | 35337..36329 | - | 993 | WP_224469586.1 | restriction endonuclease | - |
| LCH18_RS17425 (LCH18_17425) | 36487..36894 | + | 408 | WP_034617165.1 | hypothetical protein | - |
| LCH18_RS17430 (LCH18_17430) | 36936..37196 | - | 261 | WP_034617162.1 | Txe/YoeB family addiction module toxin | Toxin |
| LCH18_RS17435 (LCH18_17435) | 37180..37446 | - | 267 | WP_034617158.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| LCH18_RS17440 (LCH18_17440) | 37758..37982 | + | 225 | WP_224469588.1 | hypothetical protein | - |
| LCH18_RS17445 (LCH18_17445) | 38011..38416 | - | 406 | Protein_42 | M15 family peptidase | - |
| LCH18_RS17450 (LCH18_17450) | 38481..38639 | - | 159 | WP_155768699.1 | hypothetical protein | - |
| LCH18_RS17455 (LCH18_17455) | 38910..39152 | - | 243 | WP_224469590.1 | hypothetical protein | - |
| LCH18_RS17460 (LCH18_17460) | 39422..39697 | + | 276 | WP_034617152.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LCH18_RS17465 (LCH18_17465) | 39660..39926 | + | 267 | WP_034617149.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LCH18_RS17470 (LCH18_17470) | 40224..40436 | - | 213 | WP_034617146.1 | helix-turn-helix transcriptional regulator | - |
| LCH18_RS17475 (LCH18_17475) | 40633..40884 | + | 252 | WP_034617143.1 | hypothetical protein | - |
| LCH18_RS17480 (LCH18_17480) | 41075..42274 | - | 1200 | WP_034617140.1 | tyrosine-type recombinase/integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..84108 | 84108 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 10422.89 Da Isoelectric Point: 8.4866
>T217837 WP_034617162.1 NZ_CP083948:c37196-36936 [Acinetobacter johnsonii]
MNRTIEFTDNAWDDYIYWQTQDKKVLKRINALIKECLRTPFEGTGKPEPLKANLSGFWSRRIDEKHRLVYEVTDERISIV
QCRFHY
MNRTIEFTDNAWDDYIYWQTQDKKVLKRINALIKECLRTPFEGTGKPEPLKANLSGFWSRRIDEKHRLVYEVTDERISIV
QCRFHY
Download Length: 261 bp
>T217837 NZ_CP114891:c1290287-1289913 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9900.96 Da Isoelectric Point: 4.3516
>AT217837 WP_034617158.1 NZ_CP083948:c37446-37180 [Acinetobacter johnsonii]
MQVFTYTDARNNLKSVLDKVIDDADVAVITRKEGSHAVVMGQEHYDSLMETLYLLSSPNNAARLNESIAQLRASRTTERD
LIEDESDN
MQVFTYTDARNNLKSVLDKVIDDADVAVITRKEGSHAVVMGQEHYDSLMETLYLLSSPNNAARLNESIAQLRASRTTERD
LIEDESDN
Download Length: 267 bp
>AT217837 NZ_CP114891:c1290744-1290376 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3D2SPX3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3D2SPQ8 |