Detailed information of TA system TA217836

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 415220..415869
• Replicon: chromosome
• Accession: NZ_CP083947
• Organism: Acinetobacter johnsonii strain CSUSB1

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LCH18_RS01960
• Protein ID: WP_078426173.1
• Coordinates: 415483..415869 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N9CU98
• Locus tag: LCH18_RS01955
• Protein ID: WP_004977895.1
• Coordinates: 415220..415477 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCH18_RS01935 (LCH18_01935)	410839..411204	+	366	WP_004691290.1	50S ribosomal protein L17	-
LCH18_RS01940 (LCH18_01940)	411400..412890	+	1491	WP_224468219.1	NAD(P)/FAD-dependent oxidoreductase	-
LCH18_RS01945 (LCH18_01945)	413029..413820	+	792	WP_224468221.1	alpha/beta hydrolase	-
LCH18_RS01950 (LCH18_01950)	413855..415027	-	1173	WP_224468222.1	acyl-CoA dehydrogenase family protein	-
LCH18_RS01955 (LCH18_01955)	415220..415477	+	258	WP_004977895.1	succinate dehydrogenase assembly factor 2	Antitoxin
LCH18_RS01960 (LCH18_01960)	415483..415869	+	387	WP_078426173.1	hypothetical protein	Toxin
LCH18_RS17740	416390..417427	+	1038	WP_228748440.1	hypothetical protein	-
LCH18_RS01970 (LCH18_01970)	417499..418071	+	573	WP_004977887.1	rhombosortase	-
LCH18_RS01975 (LCH18_01975)	418254..420536	+	2283	WP_224468224.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (5-127)

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 15302.28 Da
• Isoelectric Point: 10.4419

>T217836 WP_078426173.1 NZ_CP083947:415483-415869 [Acinetobacter johnsonii]
MEHRHFQLKPSRLAYVFQLSIYAVLMLVLYQLLPLGVWLIALVAGFVLYLFFLRGPQHFQLQHLDGRDWSLSLQKQTNVQ
RVQISHIVDHRAYIVIYFQHFRAKPMLVWCDQLPITQWKALKILTKMQ

Nucleotide

• Length: 387 bp

>T217836 NZ_CP114891:1278391-1278645 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10181.71 Da
• Isoelectric Point: 4.7119

>AT217836 WP_004977895.1 NZ_CP083947:415220-415477 [Acinetobacter johnsonii]
MTEEMSLEERKVIYRARRGLKEIDVYFDPYVKNYYLQADPAEKAMFAALVEQEDPDLLDWFMEVSEPPRPEMKTLIQKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT217836 NZ_CP114891:1278143-1278394 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: N9CU98