Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 524191..524828 Replicon chromosome
Accession NZ_CP083943
Organism Bacillus velezensis strain CSUSB3

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag LCH16_RS02515 Protein ID WP_003156187.1
Coordinates 524478..524828 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID I2HMS5
Locus tag LCH16_RS02510 Protein ID WP_003156188.1
Coordinates 524191..524472 (+) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCH16_RS02490 (LCH16_02490) 520556..521155 - 600 WP_003156193.1 rhomboid family intramembrane serine protease -
LCH16_RS02495 (LCH16_02495) 521248..521613 + 366 WP_007410229.1 holo-ACP synthase -
LCH16_RS02500 (LCH16_02500) 521778..522785 + 1008 WP_007410230.1 outer membrane lipoprotein carrier protein LolA -
LCH16_RS02505 (LCH16_02505) 522902..524071 + 1170 WP_061890435.1 alanine racemase -
LCH16_RS02510 (LCH16_02510) 524191..524472 + 282 WP_003156188.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
LCH16_RS02515 (LCH16_02515) 524478..524828 + 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
LCH16_RS02520 (LCH16_02520) 524946..525767 + 822 WP_015416874.1 STAS domain-containing protein -
LCH16_RS02525 (LCH16_02525) 525772..526137 + 366 WP_003156180.1 RsbT antagonist protein RsbS -
LCH16_RS02530 (LCH16_02530) 526140..526541 + 402 WP_003156178.1 anti-sigma regulatory factor -
LCH16_RS02535 (LCH16_02535) 526553..527560 + 1008 WP_015416875.1 PP2C family protein-serine/threonine phosphatase -
LCH16_RS02540 (LCH16_02540) 527624..527953 + 330 WP_033575044.1 anti-sigma factor antagonist -
LCH16_RS02545 (LCH16_02545) 527950..528432 + 483 WP_007609591.1 anti-sigma B factor RsbW -
LCH16_RS02550 (LCH16_02550) 528398..529186 + 789 WP_003156171.1 RNA polymerase sigma factor SigB -
LCH16_RS02555 (LCH16_02555) 529186..529788 + 603 WP_007410234.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-111)

Antitoxin

(12-45)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T217833 WP_003156187.1 NZ_CP083943:524478-524828 [Bacillus velezensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

>T217833 NZ_CP114891:c589648-589319 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10562.92 Da        Isoelectric Point: 6.4706

>AT217833 WP_003156188.1 NZ_CP083943:524191-524472 [Bacillus velezensis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG

Download         Length: 282 bp

>AT217833 NZ_CP114891:c589986-589669 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8


Antitoxin

Source ID Structure
AlphaFold DB I2HMS5

References