Detailed information of TA system TA021783

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1187107..1187671
• Replicon: chromosome
• Accession: NC_008595
• Organism: Mycobacterium avium 104

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: X7VBD8
• Locus tag: MAV_RS05950
• Protein ID: WP_003875391.1
• Coordinates: 1187300..1187671 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MAV_RS25785
• Protein ID: WP_011724021.1
• Coordinates: 1187107..1187313 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MAV_RS05930	1182284..1183516	+	1233	WP_011725525.1	IS256-like element IS1245 family transposase	-
MAV_RS05935	1183595..1184032	+	438	Protein_1185	HNH endonuclease	-
MAV_RS05940	1184295..1185599	-	1305	WP_011724019.1	IS256-like element IS666 family transposase	-
MAV_RS05945	1185708..1186928	-	1221	WP_050484363.1	IS256-like element IS1311 family transposase	-
MAV_RS25785	1187107..1187313	+	207	WP_011724021.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
MAV_RS05950	1187300..1187671	+	372	WP_003875391.1	type II toxin-antitoxin system VapC family toxin	Toxin
MAV_RS05955	1187771..1188211	+	441	WP_003875392.1	nitroreductase family deazaflavin-dependent oxidoreductase	-
MAV_RS05960	1188277..1189014	-	738	WP_011724023.1	glucose 1-dehydrogenase	-
MAV_RS05965	1189110..1189715	+	606	WP_011724024.1	TetR/AcrR family transcriptional regulator; helix-turn-helix transcriptional regulator	-
MAV_RS05970	1189817..1190215	+	399	WP_011724025.1	VOC family protein	-
MAV_RS25790	1190284..1190667	+	384	WP_011724026.1	hypothetical protein	-
MAV_RS05975	1190737..1191069	+	333	WP_011724027.1	hypothetical protein	-
MAV_RS05980	1191226..1191774	+	549	WP_080516335.1	glycoside hydrolase	-
MAV_RS05985	1192185..1192508	+	324	WP_009975396.1	antibiotic biosynthesis monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13770.14 Da
• Isoelectric Point: 6.6003

>T21783 WP_003875391.1 NC_008595:1187300-1187671 [Mycobacterium avium 104]
MILVDTSVWIDHLHVADKRLIEFLTNDAIGCHQMVIEELALGAIRRRADLLRLLSNLRAFPLLTHAEVLHLVECHRLWGR
GLSAIDVHLLGSVALVDGARLWTRDKNLKAAGWDVGIAIVDEL

Nucleotide

• Length: 372 bp

>T21783 NC_008595:1187300-1187671 [Mycobacterium avium 104]
ATGATTCTCGTTGACACGTCGGTATGGATCGATCATCTGCACGTCGCCGACAAGCGACTCATAGAGTTCCTGACCAACGA
CGCAATCGGTTGCCACCAAATGGTGATCGAGGAGTTGGCATTGGGTGCGATCAGGCGGCGCGCCGATCTATTGCGCCTGC
TGTCCAATCTTCGGGCGTTCCCGTTGCTGACGCATGCGGAGGTCCTTCATCTCGTCGAATGCCACCGCTTGTGGGGCCGC
GGACTGAGTGCGATCGACGTCCATCTTCTTGGGTCGGTTGCTCTGGTCGACGGTGCACGGCTATGGACCAGGGACAAGAA
TTTAAAAGCGGCGGGCTGGGACGTGGGTATCGCGATCGTCGACGAGCTCTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7261.25 Da
• Isoelectric Point: 11.0634

>AT21783 WP_011724021.1 NC_008595:1187107-1187313 [Mycobacterium avium 104]
MRTTVTIDDALLAEAAELTGVTESVALLRQGLQTLVRVESARRLAALGGTDRKASVGPRRRTPADDSR

Nucleotide

• Length: 207 bp

>AT21783 NC_008595:1187107-1187313 [Mycobacterium avium 104]
ATGAGGACGACGGTGACGATTGACGACGCCTTATTGGCAGAGGCGGCCGAACTGACCGGGGTGACAGAGAGCGTGGCGCT
CCTCCGTCAGGGACTGCAGACACTCGTTCGGGTAGAGAGCGCCCGTCGGCTGGCGGCGCTCGGCGGCACGGATCGGAAGG
CATCGGTCGGCCCTCGCCGGAGGACACCCGCCGATGATTCTCGTTGA

Structures

Toxin

• AlphaFold DB: A0A0E2WB37