Detailed information of TA system TA217829

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 1932594..1933270
• Replicon: chromosome
• Accession: NZ_CP083938
• Organism: Comamonas thiooxydans strain CSUSB4

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LCH15_RS08895
• Protein ID: WP_224651097.1
• Coordinates: 1933088..1933270 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A5D9ANX7
• Locus tag: LCH15_RS08890
• Protein ID: WP_034358869.1
• Coordinates: 1932594..1933022 (-)
• Length: 143 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (12-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-68)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7021.07 Da
• Isoelectric Point: 10.9594

>T217829 WP_224651097.1 NZ_CP083938:c1933270-1933088 [Comamonas thiooxydans]
VVVKISEFKRWLEAQEVRVENGTNHWRLYHNGNVSTLPRHPSKELKEGTRRAILKQLGIT

Nucleotide

• Length: 183 bp

>T217829 NZ_CP114891:122603-122917 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 143 a.a.
• Molecular weight: 15324.49 Da
• Isoelectric Point: 4.8070

>AT217829 WP_034358869.1 NZ_CP083938:c1933022-1932594 [Comamonas thiooxydans]
MQKYPARFDPADEGGYTVSFRDIPEALTQGDDLADAESMARDALVTAMDFYFEDGRAVPAPSKPEKGERLVELPASVAVK
VALLNARLATGARPADVARAMGVKPQEMTRVFDLGHATKIDTVAAALAAMGYELELNVRRVK

Nucleotide

• Length: 429 bp

>AT217829 NZ_CP114891:122914-123330 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A5D9ANX7