Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1932594..1933270 Replicon chromosome
Accession NZ_CP083938
Organism Comamonas thiooxydans strain CSUSB4

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LCH15_RS08895 Protein ID WP_224651097.1
Coordinates 1933088..1933270 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A5D9ANX7
Locus tag LCH15_RS08890 Protein ID WP_034358869.1
Coordinates 1932594..1933022 (-) Length 143 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCH15_RS08845 (LCH15_08845) 1928367..1928930 + 564 WP_224650465.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
LCH15_RS08850 (LCH15_08850) 1929337..1929609 + 273 WP_003056615.1 HU family DNA-binding protein -
LCH15_RS08860 (LCH15_08860) 1929859..1930185 + 327 WP_224650466.1 hypothetical protein -
LCH15_RS08865 (LCH15_08865) 1930195..1930983 + 789 WP_224650467.1 site-specific integrase -
LCH15_RS08870 (LCH15_08870) 1930931..1931182 - 252 WP_224650468.1 helix-turn-helix domain-containing protein -
LCH15_RS08875 (LCH15_08875) 1931320..1931670 + 351 WP_224650469.1 hypothetical protein -
LCH15_RS08880 (LCH15_08880) 1931703..1931950 + 248 Protein_1698 hypothetical protein -
LCH15_RS08885 (LCH15_08885) 1932044..1932346 - 303 WP_224650470.1 hypothetical protein -
LCH15_RS08890 (LCH15_08890) 1932594..1933022 - 429 WP_034358869.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LCH15_RS08895 (LCH15_08895) 1933088..1933270 - 183 WP_224651097.1 type II toxin-antitoxin system HicA family toxin Toxin
LCH15_RS08900 (LCH15_08900) 1933371..1933625 - 255 WP_224650471.1 hypothetical protein -
LCH15_RS08905 (LCH15_08905) 1933802..1934677 + 876 WP_224648500.1 site-specific integrase -
LCH15_RS08910 (LCH15_08910) 1934687..1935883 + 1197 WP_224650472.1 IS91 family transposase -
LCH15_RS08915 (LCH15_08915) 1936567..1937406 + 840 WP_224650473.1 AlpA family phage regulatory protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 61 a.a.        Molecular weight: 7021.07 Da        Isoelectric Point: 10.9594

>T217829 WP_224651097.1 NZ_CP083938:c1933270-1933088 [Comamonas thiooxydans]
VVVKISEFKRWLEAQEVRVENGTNHWRLYHNGNVSTLPRHPSKELKEGTRRAILKQLGIT

Download         Length: 183 bp

>T217829 NZ_CP114891:122603-122917 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 15324.49 Da        Isoelectric Point: 4.8070

>AT217829 WP_034358869.1 NZ_CP083938:c1933022-1932594 [Comamonas thiooxydans]
MQKYPARFDPADEGGYTVSFRDIPEALTQGDDLADAESMARDALVTAMDFYFEDGRAVPAPSKPEKGERLVELPASVAVK
VALLNARLATGARPADVARAMGVKPQEMTRVFDLGHATKIDTVAAALAAMGYELELNVRRVK

Download         Length: 429 bp

>AT217829 NZ_CP114891:122914-123330 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A5D9ANX7

References