Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 235450..236120 | Replicon | plasmid pIncFIB_FIBK_HI1B |
| Accession | NZ_CP083933 | ||
| Organism | Klebsiella pneumoniae strain BA4946 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | Q6U619 |
| Locus tag | LCH45_RS27065 | Protein ID | WP_004213072.1 |
| Coordinates | 235450..235893 (-) | Length | 148 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | Q6U620 |
| Locus tag | LCH45_RS27070 | Protein ID | WP_004213073.1 |
| Coordinates | 235890..236120 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LCH45_RS27030 (LCH45_27065) | 230861..231136 | + | 276 | WP_004213932.1 | carboxymuconolactone decarboxylase family protein | - |
| LCH45_RS27035 (LCH45_27070) | 231199..231690 | + | 492 | WP_011251327.1 | DM13 domain-containing protein | - |
| LCH45_RS27040 (LCH45_27075) | 231739..232659 | + | 921 | WP_004213934.1 | DUF1471 domain-containing protein | - |
| LCH45_RS27045 (LCH45_27080) | 232750..233153 | + | 404 | Protein_250 | GAF domain-containing protein | - |
| LCH45_RS27050 (LCH45_27085) | 233672..234306 | - | 635 | Protein_251 | mucoid phenotype regulator RmpA2 | - |
| LCH45_RS27055 (LCH45_27090) | 234723..235027 | + | 305 | Protein_252 | transposase | - |
| LCH45_RS27060 (LCH45_27095) | 235050..235301 | - | 252 | WP_227640036.1 | hypothetical protein | - |
| LCH45_RS27065 (LCH45_27100) | 235450..235893 | - | 444 | WP_004213072.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LCH45_RS27070 (LCH45_27105) | 235890..236120 | - | 231 | WP_004213073.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| LCH45_RS27075 (LCH45_27110) | 236728..237861 | + | 1134 | WP_004213075.1 | DUF3800 domain-containing protein | - |
| LCH45_RS27080 (LCH45_27115) | 237877..238170 | + | 294 | WP_004213076.1 | hypothetical protein | - |
| LCH45_RS27085 (LCH45_27120) | 238160..238366 | - | 207 | WP_004213077.1 | hypothetical protein | - |
| LCH45_RS27090 (LCH45_27125) | 238718..239008 | + | 291 | WP_004213078.1 | hypothetical protein | - |
| LCH45_RS27095 (LCH45_27130) | 238998..239897 | + | 900 | WP_004225022.1 | nucleotide-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaCTX-M-15 / blaTEM-1A / tet(D) / dfrA14 / blaOXA-1 / aac(6')-Ib-cr / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 | iucA / iucB / iucC / iucD / iutA / rmpA | 1..421072 | 421072 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 148 a.a. Molecular weight: 16006.74 Da Isoelectric Point: 9.3642
>T217826 WP_004213072.1 NZ_CP083933:c235893-235450 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
Download Length: 444 bp
>T217826 NZ_CP114886:6035666-6035923 [Endozoicomonas sp. GU-1]
ATGAAAGTCGTGTCCTATTCCGAAGCCCGGAACAATCTGAAATCCGTTCTTGATCAGGTGGCAGAGGATGCCAGTGAAAC
CCTGATTCATCGCCGTGACGGTCAGGATGCTGTTGTAATGTCGCTGGACAGCTACAACAGCCTGATGGAAACCCTGCACC
TGATGTCATCCCCGGCCAACGCCCAACACCTGAACGACTCCATTGAGCAGATCAGGACCGGGCAGGTCATGGAACGGGGA
TTGCTGGATGACCGATAA
ATGAAAGTCGTGTCCTATTCCGAAGCCCGGAACAATCTGAAATCCGTTCTTGATCAGGTGGCAGAGGATGCCAGTGAAAC
CCTGATTCATCGCCGTGACGGTCAGGATGCTGTTGTAATGTCGCTGGACAGCTACAACAGCCTGATGGAAACCCTGCACC
TGATGTCATCCCCGGCCAACGCCCAACACCTGAACGACTCCATTGAGCAGATCAGGACCGGGCAGGTCATGGAACGGGGA
TTGCTGGATGACCGATAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8677.73 Da Isoelectric Point: 4.4563
>AT217826 WP_004213073.1 NZ_CP083933:c236120-235890 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT217826 NZ_CP114886:6035913-6036182 [Endozoicomonas sp. GU-1]
ATGACCGATAAGCACCGACTGCTTTGCTGGTCACACAATGCCTGGAACGATTACCTGTACTGGCAGGAGCAGGACCGGAA
AACCCTGAAGCGCATCAATAAACTAATAACCGAGTGTCTGCGCGACCCATTTAAGGGTATTGGCAAACCCGAGCCGCTGA
AAGGTAACTGGCAGGGGTTCTGGTCACGGCGGATCAGCGATGAACACCGGCTGGTCTATCAGGCCACAGATGCCCGACTG
ATCATTGCTGCCTGCCGGTTTCACTACTAA
ATGACCGATAAGCACCGACTGCTTTGCTGGTCACACAATGCCTGGAACGATTACCTGTACTGGCAGGAGCAGGACCGGAA
AACCCTGAAGCGCATCAATAAACTAATAACCGAGTGTCTGCGCGACCCATTTAAGGGTATTGGCAAACCCGAGCCGCTGA
AAGGTAACTGGCAGGGGTTCTGGTCACGGCGGATCAGCGATGAACACCGGCTGGTCTATCAGGCCACAGATGCCCGACTG
ATCATTGCTGCCTGCCGGTTTCACTACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|