Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 58400..59310 | Replicon | plasmid pIncFIB_FIBK_HI1B |
| Accession | NZ_CP083933 | ||
| Organism | Klebsiella pneumoniae strain BA4946 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A5Q9LR54 |
| Locus tag | LCH45_RS26165 | Protein ID | WP_004181896.1 |
| Coordinates | 58840..59310 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | LCH45_RS26160 | Protein ID | WP_004181895.1 |
| Coordinates | 58400..58843 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LCH45_RS26145 (LCH45_26170) | 55033..56520 | + | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
| LCH45_RS26150 (LCH45_26175) | 56606..57028 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| LCH45_RS26155 (LCH45_26180) | 57028..58299 | + | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| LCH45_RS26160 (LCH45_26185) | 58400..58843 | + | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| LCH45_RS26165 (LCH45_26190) | 58840..59310 | + | 471 | WP_004181896.1 | RES family NAD+ phosphorylase | Toxin |
| LCH45_RS26170 (LCH45_26195) | 59420..59680 | - | 261 | WP_004026352.1 | hypothetical protein | - |
| LCH45_RS26175 (LCH45_26200) | 60251..61432 | - | 1182 | WP_004883380.1 | IS481 family transposase | - |
| LCH45_RS26180 | 61504..61665 | + | 162 | WP_004118124.1 | type I toxin-antitoxin system Hok family toxin | - |
| LCH45_RS26185 (LCH45_26215) | 62365..62637 | + | 273 | WP_004152759.1 | hypothetical protein | - |
| LCH45_RS26190 (LCH45_26220) | 62634..62984 | + | 351 | WP_004152758.1 | hypothetical protein | - |
| LCH45_RS26195 (LCH45_26225) | 63620..63976 | + | 357 | WP_004152717.1 | hypothetical protein | - |
| LCH45_RS26200 (LCH45_26230) | 64037..64249 | + | 213 | WP_004152718.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaCTX-M-15 / blaTEM-1A / tet(D) / dfrA14 / blaOXA-1 / aac(6')-Ib-cr / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 | iucA / iucB / iucC / iucD / iutA / rmpA | 1..421072 | 421072 | |
| - | flank | IS/Tn | - | - | 60251..61432 | 1181 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17549.81 Da Isoelectric Point: 4.6155
>T217825 WP_004181896.1 NZ_CP083933:58840-59310 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
>T217825 NZ_CP114886:5989397-5989684 [Endozoicomonas sp. GU-1]
ATGAGCAGGAAGCTAAAGACCTTTGATGCATCAGAGTATCTTGACGACAGTGAAACTATTGCAGAGTACTTGAATGCAGT
CATCGAAACGGGTGACCAAGCTTTGCTCTTATCGGCTATTGGTGATATCGCCAAGGCAACAGGGATGCAGAAGATAGCCA
ATGACTCAGGCCTCGGTCGGGAAAGTTTATACAAAGCCCTGGCACCAGGTGCGAAACCAAGATTTGATACAGTGTTCAAA
ATTCTTCAGGCCCTGGGAGTGAGTTTGAAAATCAGCCCTCAGCATTAG
ATGAGCAGGAAGCTAAAGACCTTTGATGCATCAGAGTATCTTGACGACAGTGAAACTATTGCAGAGTACTTGAATGCAGT
CATCGAAACGGGTGACCAAGCTTTGCTCTTATCGGCTATTGGTGATATCGCCAAGGCAACAGGGATGCAGAAGATAGCCA
ATGACTCAGGCCTCGGTCGGGAAAGTTTATACAAAGCCCTGGCACCAGGTGCGAAACCAAGATTTGATACAGTGTTCAAA
ATTCTTCAGGCCCTGGGAGTGAGTTTGAAAATCAGCCCTCAGCATTAG
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT217825 WP_004181895.1 NZ_CP083933:58400-58843 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT217825 NZ_CP114886:5989018-5989395 [Endozoicomonas sp. GU-1]
ATGAAAGACCTGACCCCCGGTTTTTTTCCGTTTTTTGTGTGTGAACTTGAATATGTATCCAAATGGATACATAATTCCTT
AATGTACTTGCTCAAGACCACTGACCACTTCGAGAAGTGGCTGCACAAACTTAAAGACAAGCAGGGCAAGGCTCGAATCC
TGGCCTCTCTTAAATTGCTGGAGCAGGGACACATCGGGGACTGGAAATCAGTTGGAGGCAAAGTGTCAGAACTTCGGGTG
CACTACGGGGCAGGCTATAGGATCTACTTTGCCAGGCAAGAGGATGTCATCATCGTATTACTCAATGGTGGTGACAAGGC
CAGCCAGTCCAGAGACATTGAAAAAGCAAAAGCCATTTTAAAAAATCTGGAGGCATGA
ATGAAAGACCTGACCCCCGGTTTTTTTCCGTTTTTTGTGTGTGAACTTGAATATGTATCCAAATGGATACATAATTCCTT
AATGTACTTGCTCAAGACCACTGACCACTTCGAGAAGTGGCTGCACAAACTTAAAGACAAGCAGGGCAAGGCTCGAATCC
TGGCCTCTCTTAAATTGCTGGAGCAGGGACACATCGGGGACTGGAAATCAGTTGGAGGCAAAGTGTCAGAACTTCGGGTG
CACTACGGGGCAGGCTATAGGATCTACTTTGCCAGGCAAGAGGATGTCATCATCGTATTACTCAATGGTGGTGACAAGGC
CAGCCAGTCCAGAGACATTGAAAAAGCAAAAGCCATTTTAAAAAATCTGGAGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q9LR54 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |