Detailed information of TA system TA217823

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4947274..4948955
• Replicon: chromosome
• Accession: NZ_CP083932
• Organism: Klebsiella pneumoniae strain BA4946

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: LCH45_RS23920
• Protein ID: WP_004178299.1
• Coordinates: 4947274..4948191 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: LCH45_RS23925
• Protein ID: WP_004177809.1
• Coordinates: 4948197..4948955 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCH45_RS23900 (4942580)	4942580..4944100	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
LCH45_RS23905 (4944097)	4944097..4945095	+	999	WP_002885172.1	ribose ABC transporter permease	-
LCH45_RS23910 (4945126)	4945126..4946067	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
LCH45_RS23915 (4946142)	4946142..4947149	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
LCH45_RS23920 (4947274)	4947274..4948191	-	918	WP_004178299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LCH45_RS23925 (4948197)	4948197..4948955	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
LCH45_RS23930 (4949041)	4949041..4949769	-	729	WP_004178298.1	response regulator transcription factor	-
LCH45_RS23935 (4950042)	4950042..4952189	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
LCH45_RS23940 (4952419)	4952419..4953105	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T217823 WP_004178299.1 NZ_CP083932:c4948191-4947274 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T217823 NZ_CP114886:c5962267-5961971 [Endozoicomonas sp. GU-1]
ATGAAACTCAGGTTTTCCAGGAGTGCCGTTGATGACCTGAAACGACTGAGACAGTTTATTGCAGAAAAAAATCCGCCTGC
GGCACAGCGAATGGCGGAGTATTTGGTCAGGAAAATTAACAACCTGTGTCATCAACCGAACATGGGCGTTCTGGTAGGGG
ATAAACTGAATCCCCGTTTGCGTGACCTGATCATTAGGGATTACAAGATTCGCTATCTTGCTGACGACCGTGAGGTCTTG
ATTCTGAAGATATGGCATCAGAAAGAGGCTGATGAGATCAGCCTTGACTCAGAGTGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT217823 WP_004177809.1 NZ_CP083932:c4948955-4948197 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT217823 NZ_CP114886:c5962527-5962264 [Endozoicomonas sp. GU-1]
ATGAGTGTATCCAGCGTTCGTCTGAATCAGGATATTGAAGAACCGTTAAACCAATTAGCCAAAGTGTTGAGCCGTAGTCG
GAACTATCTTATTAACGAAGCGGTCAGGGAGTACATCAAGAAACACGCCCGTGAAATGCAAGAGTGGGACGAGACCCTGG
AAGCACTGGATCAGGTGCGCAGGGGAGATACCGTAGATGGTGACGCCGTGATGGAATGGCTGGAAAGTTGGGGCAGTGAT
AATGAGCTGGAGGCACCTGAATGA

Structures

Antitoxin

• AlphaFold DB: A6TH05