Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4791579..4792095 Replicon chromosome
Accession NZ_CP083932
Organism Klebsiella pneumoniae strain BA4946

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag LCH45_RS23125 Protein ID WP_004178374.1
Coordinates 4791579..4791863 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LCH45_RS23130 Protein ID WP_002886901.1
Coordinates 4791853..4792095 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCH45_RS23100 (4787063) 4787063..4787326 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
LCH45_RS23105 (4787456) 4787456..4787629 + 174 WP_032408826.1 hypothetical protein -
LCH45_RS23110 (4787632) 4787632..4788375 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LCH45_RS23115 (4788732) 4788732..4790870 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LCH45_RS23120 (4791111) 4791111..4791575 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LCH45_RS23125 (4791579) 4791579..4791863 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LCH45_RS23130 (4791853) 4791853..4792095 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LCH45_RS23135 (4792173) 4792173..4794083 - 1911 WP_004178373.1 PRD domain-containing protein -
LCH45_RS23140 (4794106) 4794106..4795260 - 1155 WP_004178372.1 lactonase family protein -
LCH45_RS23145 (4795327) 4795327..4796067 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T217822 WP_004178374.1 NZ_CP083932:c4791863-4791579 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T217822 NZ_CP114886:c5943211-5942822 [Endozoicomonas sp. GU-1]
ATGGTTGATACCGATATTTGTATTGCGGTTTTAAAACATAATCGCCCGGTCATTGATAAGTTTATTGAGCATCAGGGGAA
GGTCTATGTTTCATCCATTTCCTGTTACGAGTTGCAGTTCGGCATTGAAAAAGGTGACCCTGAACACAGGCAGGGCAAGG
AAAGTAAGCTGTCGTTCTTTTTAGAGGGAGTGAACGTGATCGACTTTGACGGGGCAGCCGCCCGGGAGTCAGCAAAAGTC
AGAGAGGAATTGCAAAGGGGGCAACAAATTGGTGCTTATGATACCTTGCTGGCAGCCCATGCCAGAAGCCGGGGGATGGT
AATGGTCACTCATAATCAGCGGGAATTTTCTAGAGTCCCCGGATTGCAACTTGCCGATTGGTTGGGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT217822 WP_002886901.1 NZ_CP083932:c4792095-4791853 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT217822 NZ_CP114886:c5943444-5943223 [Endozoicomonas sp. GU-1]
ATGGAGACCAGCGTATTTTTTAACAATAAAACGCAGGCTGTCAGAATTCCGAAAGAGCTTGCCTTTCCGGATACGGTTAA
GCGAGTCATGGTGCGTAAAGAAGGAAAAGCCATCATCCTGACGCCGATCGAAGACTACTGGGAAACATTTCTGGCGATGG
AACCCATTGATGATTTTCCAGAGCGGGAGCAACCGGCCTGTCAGGATCGGGAGGACTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References