Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4086524..4087143 Replicon chromosome
Accession NZ_CP083932
Organism Klebsiella pneumoniae strain BA4946

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LCH45_RS19840 Protein ID WP_002892050.1
Coordinates 4086925..4087143 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LCH45_RS19835 Protein ID WP_002892066.1
Coordinates 4086524..4086898 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCH45_RS19825 (4081676) 4081676..4082869 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LCH45_RS19830 (4082892) 4082892..4086038 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LCH45_RS19835 (4086524) 4086524..4086898 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LCH45_RS19840 (4086925) 4086925..4087143 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LCH45_RS19845 (4087302) 4087302..4087868 + 567 WP_002892030.1 maltose O-acetyltransferase -
LCH45_RS19850 (4087840) 4087840..4087980 - 141 WP_004147370.1 hypothetical protein -
LCH45_RS19855 (4088001) 4088001..4088471 + 471 WP_002892026.1 YlaC family protein -
LCH45_RS19860 (4088446) 4088446..4089897 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LCH45_RS19865 (4089998) 4089998..4090696 + 699 WP_004178762.1 GNAT family protein -
LCH45_RS19870 (4090693) 4090693..4090833 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LCH45_RS19875 (4090833) 4090833..4091096 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T217820 WP_002892050.1 NZ_CP083932:4086925-4087143 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T217820 NZ_CP114886:5238812-5239087 [Endozoicomonas sp. GU-1]
ATGGGTAATACCCAGTTTGAATACGATGAAGAAAAAAGTCTTGCCAACAAGGATAAGCATGGCATCGACTTTGTGCAGGC
AGCCACCTTATGGGAGGATGATAGACTGATCTGCCTGCAATCGAAGGTAAAGACCGATGAGGACCGATTACTCTTTATCG
GTCAAATAACAACTAAACACTGGACCGCCATAGCGACACAACGGAGAGACTGTCTCAGAATTATCTTAGTACGCCGATCC
AGAAAAAATGAGGTGAACCTTTATGAAAGCCAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT217820 WP_002892066.1 NZ_CP083932:4086524-4086898 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT217820 NZ_CP114886:5239074-5239295 [Endozoicomonas sp. GU-1]
ATGAAAGCCAGTGATATTGATAAAAAATTCGACGATGGCGAAGACGTACTGGAATTCTTCGACACCGACCATCCTCAACG
GCCCAACCTTGCAGCCAAAAGGGTCAACATTGACTTCCCTGCATGGGTTGTCAATGAGCTGGATAAAGAAGCCAGCGCAA
TCGGCATCAGCCGTCAGGCGCTGATTAAAACGTGGATTGTTGACCGGCTCAGGCAGCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References