Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2787555..2789143 Replicon chromosome
Accession NZ_CP083932
Organism Klebsiella pneumoniae strain BA4946

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LCH45_RS13715 Protein ID WP_004179815.1
Coordinates 2787555..2788877 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LCH45_RS13720 Protein ID WP_004176198.1
Coordinates 2788877..2789143 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCH45_RS13700 (2782611) 2782611..2785112 + 2502 WP_004179823.1 fimbria/pilus outer membrane usher protein -
LCH45_RS13705 (2785100) 2785100..2786104 + 1005 WP_004179822.1 fimbrial protein -
LCH45_RS13710 (2786246) 2786246..2787538 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LCH45_RS13715 (2787555) 2787555..2788877 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
LCH45_RS13720 (2788877) 2788877..2789143 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LCH45_RS13725 (2789409) 2789409..2789735 - 327 WP_002904788.1 hydroxyisourate hydrolase -
LCH45_RS13730 (2789732) 2789732..2790232 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LCH45_RS13735 (2790210) 2790210..2791589 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
LCH45_RS13740 (2791935) 2791935..2793089 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LCH45_RS13745 (2793070) 2793070..2793993 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T217818 WP_004179815.1 NZ_CP083932:c2788877-2787555 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T217818 NZ_CP114886:5010661-5010816 [Endozoicomonas sp. GU-1]
ATGATTTTATGGGAAGAAGAGTCTCTGAATGATCGGGAAAAGATCTTTGAGTTTCTTTATGATTTTAATCCTGAAGCCGC
AGAAAAGACTGATCTGATCATAGAAACGAAAGTCGAAAACTTATTAGAACAACCGCTTATGGGGGGGGCAGCGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT217818 WP_004176198.1 NZ_CP083932:c2789143-2788877 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT217818 NZ_CP114886:5010377-5010661 [Endozoicomonas sp. GU-1]
ATGGAAACAAGAATACAATTTCGAGTCGATGAGGAAACAAAACGCCTGGCTCAAAAAATGGCTGAAAGTCAGGGGCGCAC
TATCAGTGATGCATGCCGGGAGTTTACTGAGCAACTGGCTGAACAACAGCGTAAGTTATCCTCCCACGATCAATGGCTAA
CCCAACAAGTCAACCAGGCATTTGAGAAACTGGACTCTGGAGCAACGAATTTTGCTGAACACGATAAAGCCAAAGACGAG
ATGGCTAAGCGCAAAGCGAAAATTCGCAACAGAGGCAGCCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References