Detailed information of TA system TA217818

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2787555..2789143
• Replicon: chromosome
• Accession: NZ_CP083932
• Organism: Klebsiella pneumoniae strain BA4946

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LCH45_RS13715
• Protein ID: WP_004179815.1
• Coordinates: 2787555..2788877 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LCH45_RS13720
• Protein ID: WP_004176198.1
• Coordinates: 2788877..2789143 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCH45_RS13700 (2782611)	2782611..2785112	+	2502	WP_004179823.1	fimbria/pilus outer membrane usher protein	-
LCH45_RS13705 (2785100)	2785100..2786104	+	1005	WP_004179822.1	fimbrial protein	-
LCH45_RS13710 (2786246)	2786246..2787538	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
LCH45_RS13715 (2787555)	2787555..2788877	-	1323	WP_004179815.1	type II toxin-antitoxin system HipA family toxin	Toxin
LCH45_RS13720 (2788877)	2788877..2789143	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LCH45_RS13725 (2789409)	2789409..2789735	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
LCH45_RS13730 (2789732)	2789732..2790232	-	501	WP_004179811.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LCH45_RS13735 (2790210)	2790210..2791589	-	1380	WP_004179808.1	nucleobase:cation symporter-2 family protein	-
LCH45_RS13740 (2791935)	2791935..2793089	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
LCH45_RS13745 (2793070)	2793070..2793993	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T217818 WP_004179815.1 NZ_CP083932:c2788877-2787555 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T217818 NZ_CP114886:5010661-5010816 [Endozoicomonas sp. GU-1]
ATGATTTTATGGGAAGAAGAGTCTCTGAATGATCGGGAAAAGATCTTTGAGTTTCTTTATGATTTTAATCCTGAAGCCGC
AGAAAAGACTGATCTGATCATAGAAACGAAAGTCGAAAACTTATTAGAACAACCGCTTATGGGGGGGGCAGCGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT217818 WP_004176198.1 NZ_CP083932:c2789143-2788877 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT217818 NZ_CP114886:5010377-5010661 [Endozoicomonas sp. GU-1]
ATGGAAACAAGAATACAATTTCGAGTCGATGAGGAAACAAAACGCCTGGCTCAAAAAATGGCTGAAAGTCAGGGGCGCAC
TATCAGTGATGCATGCCGGGAGTTTACTGAGCAACTGGCTGAACAACAGCGTAAGTTATCCTCCCACGATCAATGGCTAA
CCCAACAAGTCAACCAGGCATTTGAGAAACTGGACTCTGGAGCAACGAATTTTGCTGAACACGATAAAGCCAAAGACGAG
ATGGCTAAGCGCAAAGCGAAAATTCGCAACAGAGGCAGCCAGTGA