Detailed information of TA system TA021781

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ygfYX/Cpta(toxin)
• Location: 3639717..3640377
• Replicon: chromosome
• Accession: NC_008577
• Organism: Shewanella sp. ANA-3

Toxin (Protein)

• Gene name: ygfX
• Uniprot ID: A0KZP0
• Locus tag: SHEWANA3_RS15930
• Protein ID: WP_011717879.1
• Coordinates: 3639717..3640157 (-)
• Length: 147 a.a.

Antitoxin (Protein)

• Gene name: ygfY
• Uniprot ID: -
• Locus tag: SHEWANA3_RS15935
• Protein ID: WP_011717880.1
• Coordinates: 3640138..3640377 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SHEWANA3_RS15905	3635165..3635638	-	474	WP_011717875.1	SoxR reducing system RseC family protein	-
SHEWANA3_RS15910	3635650..3636582	-	933	WP_011717876.1	MucB/RseB C-terminal domain-containing protein	-
SHEWANA3_RS15915	3636595..3637218	-	624	WP_011717877.1	anti-sigma factor	-
SHEWANA3_RS15920	3637245..3637823	-	579	WP_011623604.1	RNA polymerase sigma factor RpoE	-
SHEWANA3_RS15925	3638013..3639626	+	1614	WP_011717878.1	L-aspartate oxidase	-
SHEWANA3_RS15930	3639717..3640157	-	441	WP_011717879.1	hypothetical protein	Toxin
SHEWANA3_RS15935	3640138..3640377	-	240	WP_011717880.1	succinate dehydrogenase assembly factor 2	Antitoxin
SHEWANA3_RS15940	3640469..3641377	-	909	WP_011717881.1	transcriptional activator NhaR	-
SHEWANA3_RS15945	3641473..3641859	-	387	WP_011717882.1	hypothetical protein	-
SHEWANA3_RS15950	3641862..3643031	-	1170	WP_011717883.1	Na+/H+ antiporter NhaA	-
SHEWANA3_RS15955	3643150..3643944	-	795	WP_011717884.1	thymidylate synthase	-
SHEWANA3_RS15960	3643944..3644750	-	807	WP_011717885.1	prolipoprotein diacylglyceryl transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (5-134)

Antitoxin

• Flavinator of succinate dehydrogenase (4-74)

Sequences

Toxin

Protein

• Length: 147 a.a.
• Molecular weight: 17137.11 Da
• Isoelectric Point: 8.7977

>T21781 WP_011717879.1 NC_008577:c3640157-3639717 [Shewanella sp. ANA-3]
VAERRHSFSVKASSDQRLSLVVFVCVCSTSLLIWPETDVIFWLVLKLVFAVLILGFLGYQLWRLRTWHYRFELNGKGEGW
LSTGEAFYVLPKTWVTPFVCLMYYQSADKLYLLPLWADMFSDTDYRHLCRLLLKVKTQATSQRESL

Nucleotide

• Length: 441 bp

>T21781 NC_008577:c3640157-3639717 [Shewanella sp. ANA-3]
GTGGCAGAGCGGCGCCATAGTTTTAGCGTAAAAGCCTCTAGCGACCAGCGACTCTCGTTGGTCGTTTTTGTTTGTGTCTG
CAGTACCTCTTTACTTATCTGGCCTGAAACGGACGTTATATTTTGGCTTGTGCTTAAGTTGGTGTTCGCCGTTTTAATCC
TCGGATTCTTGGGCTATCAGTTATGGCGACTGAGGACTTGGCATTACCGTTTTGAACTCAATGGAAAAGGGGAAGGCTGG
CTCTCGACGGGGGAGGCGTTTTATGTGCTCCCGAAAACTTGGGTAACGCCCTTTGTCTGCTTAATGTACTATCAGTCCGC
CGATAAGTTGTATCTCTTGCCCCTGTGGGCCGATATGTTTAGCGATACAGATTACCGCCACTTATGCCGTTTATTACTCA
AGGTTAAAACTCAGGCGACGAGCCAACGCGAGTCCCTTTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9185.62 Da
• Isoelectric Point: 4.4217

>AT21781 WP_011717880.1 NC_008577:c3640377-3640138 [Shewanella sp. ANA-3]
MNIARVRWACRRGMLELDVLFQPFVENVYQDLSDDDKALFIRLLECEDPELFAWFMGHEACPDAELARMVVQVRGRAAP

Nucleotide

• Length: 240 bp

>AT21781 NC_008577:c3640377-3640138 [Shewanella sp. ANA-3]
ATGAACATTGCACGGGTCCGCTGGGCATGTCGCCGCGGAATGCTCGAATTGGACGTCTTGTTCCAGCCTTTCGTCGAAAA
TGTTTATCAGGATTTGTCGGATGACGACAAGGCCCTGTTTATTCGTTTACTCGAGTGTGAAGACCCTGAATTATTTGCTT
GGTTTATGGGTCATGAAGCCTGTCCCGATGCCGAGCTTGCCCGCATGGTAGTGCAAGTCCGTGGCAGAGCGGCGCCATAG

Structures

Toxin

• AlphaFold DB: A0KZP0