Detailed information of TA system TA217809

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 814903..815560
• Replicon: chromosome
• Accession: NZ_CP083932
• Organism: Klebsiella pneumoniae strain BA4946

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LCH45_RS04010
• Protein ID: WP_004181233.1
• Coordinates: 815150..815560 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: LCH45_RS04005
• Protein ID: WP_002916312.1
• Coordinates: 814903..815169 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCH45_RS03980 (810059)	810059..811492	-	1434	WP_004181234.1	6-phospho-beta-glucosidase	-
LCH45_RS03985 (811611)	811611..812339	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
LCH45_RS03990 (812389)	812389..812700	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
LCH45_RS03995 (812864)	812864..813523	+	660	WP_002916317.1	hemolysin III family protein	-
LCH45_RS04000 (813674)	813674..814657	-	984	WP_002916313.1	tRNA-modifying protein YgfZ	-
LCH45_RS04005 (814903)	814903..815169	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
LCH45_RS04010 (815150)	815150..815560	+	411	WP_004181233.1	protein YgfX	Toxin
LCH45_RS04015 (815567)	815567..816088	-	522	WP_004144730.1	flavodoxin FldB	-
LCH45_RS04020 (816189)	816189..817085	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
LCH45_RS04025 (817108)	817108..817821	+	714	WP_002916301.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
LCH45_RS04030 (817827)	817827..819560	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16121.92 Da
• Isoelectric Point: 11.1565

>T217809 WP_004181233.1 NZ_CP083932:815150-815560 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T217809 NZ_CP114871:c712951-712655 [Caulobacter sp. NIBR2454]
ATGACCGCAACCACGCCGTTCAATGCAGCTGACCATATCGAGACGCCCGAGCAAGCCGCGGTGTTTCTCGATGAAGCCTT
GGCGACCGGCGACGCGGGCTACATCCAGCATGCCCTGGGGGTTCTGGCGAGGTCCAAGGGCATGACCCATCTGGCCGACG
CGACAGGCCTTGGGCGTCAAGGTCTATACAAGGCTCTGGCGGAGGACGGCTCGCCCAAGTTCGAGACCGTATTGAATGTC
GTCAGGGCTCTCGGCATTCAGCTGCACGCGACGTTGGCGGACCAGGCCGCCGCATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT217809 WP_002916312.1 NZ_CP083932:814903-815169 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT217809 NZ_CP114871:c713297-712995 [Caulobacter sp. NIBR2454]
GTGGTTGAAGTCCGTCAGACGGCCGAGTTCGCCGCTTGGTTCGGTGGACTAAGGGATCTGGTCGCCCGCACGCGGATCAC
CGCCCGGATCGACCAACTCGCCTACGGCTTGAAGGGGGACGTAAAAGCCGTTGGCGAGGGCGTGCGCGAACTGCGGATCC
ATGTCGGGCCAGGATACCGCGTCTACATCAAGGAGCACGGCGGGACGCTGACCATCCTGCTCTGCGGCGGAGATAAAAGC
TCTCAGGAGCGAGACATTCGGCGGGCGAAGGAGATCGCCAGACGGGTCGTGAAGACGCCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41