Detailed information of TA system TA217806

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 1584408..1584915
• Replicon: chromosome
• Accession: NZ_CP083931
• Organism: Alysiella filiformis DSM 16848

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: JF568_RS07725
• Protein ID: WP_097113728.1
• Coordinates: 1584408..1584674 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: JF568_RS07730
• Protein ID: WP_097113727.1
• Coordinates: 1584661..1584915 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JF568_RS07705 (JF568_07705)	1582103..1582768	-	666	WP_097113732.1	7-cyano-7-deazaguanine synthase QueC	-
JF568_RS07710 (JF568_07710)	1582761..1582949	-	189	WP_097113731.1	NF038104 family lipoprotein	-
JF568_RS07715 (JF568_07715)	1583187..1583714	+	528	WP_097113826.1	disulfide bond formation protein B	-
JF568_RS07720 (JF568_07720)	1583719..1584321	+	603	WP_097113729.1	nicotinate (nicotinamide) nucleotide adenylyltransferase	-
JF568_RS07725 (JF568_07725)	1584408..1584674	+	267	WP_097113728.1	BrnT family toxin	Toxin
JF568_RS07730 (JF568_07730)	1584661..1584915	+	255	WP_097113727.1	CopG family antitoxin	Antitoxin
JF568_RS07735 (JF568_07735)	1584929..1585402	+	474	WP_097113726.1	preQ(1) synthase	-
JF568_RS07740 (JF568_07740)	1585432..1585878	+	447	WP_143269103.1	hypothetical protein	-
JF568_RS07745 (JF568_07745)	1585973..1586254	+	282	WP_097113825.1	BrnT family toxin	-
JF568_RS07750 (JF568_07750)	1586241..1586537	+	297	WP_097113724.1	BrnA antitoxin family protein	-
JF568_RS07755 (JF568_07755)	1586685..1587359	+	675	WP_097113723.1	7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter	-
JF568_RS07760 (JF568_07760)	1587843..1588451	+	609	WP_097113721.1	DUF4230 domain-containing protein	-
JF568_RS07765 (JF568_07765)	1588533..1589588	+	1056	WP_097113720.1	metallophosphoesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1561611..1586537	24926

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

• CopG antitoxin (16-75)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10519.91 Da
• Isoelectric Point: 7.5211

>T217806 WP_097113728.1 NZ_CP083931:1584408-1584674 [Alysiella filiformis DSM 16848]
MFEFEYDPNKSQSNHTKHGIDFETAQYLWQDPQLLSIPIQTEPEIRHLAIGIIGEKHWSAIYTHRNGKIRLISVRRSRDK
EKMLYETH

Nucleotide

• Length: 267 bp

>T217806 NZ_CP114853:c5255091-5254708 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9904.28 Da
• Isoelectric Point: 5.0623

>AT217806 WP_097113727.1 NZ_CP083931:1584661-1584915 [Alysiella filiformis DSM 16848]
MKPIDTEVFERKFDDNQEDILEYLDLSQATRVHQNKIATRRVNVDFPLWMLESLDREAANLGVARQALIKMWLSQHLPPN
QQNI

Nucleotide

• Length: 255 bp

>AT217806 NZ_CP114853:c5255333-5255091 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA