Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1534954..1535462 Replicon chromosome
Accession NZ_CP083930
Organism Simonsiella muelleri strain DSM 2579

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JF634_RS07670 Protein ID WP_104930313.1
Coordinates 1534954..1535214 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag JF634_RS07675 Protein ID WP_104930314.1
Coordinates 1535205..1535462 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JF634_RS07655 (JF634_07655) 1532064..1532765 + 702 WP_002643086.1 type IV secretion system protein -
JF634_RS07660 (JF634_07660) 1532762..1533583 + 822 WP_002643087.1 TrbG/VirB9 family P-type conjugative transfer protein -
JF634_RS07665 (JF634_07665) 1533596..1534906 + 1311 WP_002643088.1 type IV secretion system protein VirB10 -
JF634_RS07670 (JF634_07670) 1534954..1535214 - 261 WP_104930313.1 Txe/YoeB family addiction module toxin Toxin
JF634_RS07675 (JF634_07675) 1535205..1535462 - 258 WP_104930314.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JF634_RS07680 (JF634_07680) 1535526..1536428 + 903 WP_224451198.1 P-type DNA transfer ATPase VirB11 -
JF634_RS07685 (JF634_07685) 1536640..1536834 + 195 WP_002641864.1 hypothetical protein -
JF634_RS07690 (JF634_07690) 1536788..1537096 + 309 WP_224451199.1 type II toxin-antitoxin system RelE/ParE family toxin -
JF634_RS07695 (JF634_07695) 1537192..1538193 + 1002 WP_002641862.1 IS5 family transposase -
JF634_RS07700 (JF634_07700) 1538331..1538777 - 447 Protein_1494 lytic transglycosylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10501.98 Da        Isoelectric Point: 7.2761

>T217804 WP_104930313.1 NZ_CP083930:c1535214-1534954 [Simonsiella muelleri]
MRLTFSDDAWDDYIFWQTTDRKILKRINTLIKDIKRNPFDGIGKPEPLRFHLSGFWSRRIDEEHRLVYAIENEQILIASC
RYHYVE

Download         Length: 261 bp

>T217804 NZ_CP114853:c4770563-4770279 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9911.26 Da        Isoelectric Point: 7.1332

>AT217804 WP_104930314.1 NZ_CP083930:c1535462-1535205 [Simonsiella muelleri]
MYTLTYSEARQNLAKTMQEVVQNHEPVLITRAKNEDCVLMSLSHYRSLEETAYLLRSPANAKRLQRSIEQLRQNGGKERE
LIECD

Download         Length: 258 bp

>AT217804 NZ_CP114853:c4770795-4770553 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGGTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References