Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ParE-CopA/ParE-RHH
Location 2125453..2126018 Replicon chromosome
Accession NC_008577
Organism Shewanella sp. ANA-3

Toxin (Protein)


Gene name parE Uniprot ID A0KW60
Locus tag SHEWANA3_RS09475 Protein ID WP_011716806.1
Coordinates 2125453..2125746 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name copA Uniprot ID A0A448EM94
Locus tag SHEWANA3_RS09480 Protein ID WP_011716807.1
Coordinates 2125734..2126018 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SHEWANA3_RS09455 2121402..2122307 + 906 WP_166485347.1 cytoplasmic protein -
SHEWANA3_RS09460 2122596..2122814 + 219 WP_041412607.1 AlpA family phage regulatory protein -
SHEWANA3_RS09465 2122846..2124315 + 1470 WP_011716804.1 DUF3987 domain-containing protein -
SHEWANA3_RS09470 2124630..2125307 + 678 WP_011716805.1 inovirus Gp2 family protein -
SHEWANA3_RS09475 2125453..2125746 - 294 WP_011716806.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SHEWANA3_RS09480 2125734..2126018 - 285 WP_011716807.1 CopG family ribbon-helix-helix protein Antitoxin
SHEWANA3_RS09485 2126305..2127027 - 723 WP_011716808.1 lecithin retinol acyltransferase family protein -
SHEWANA3_RS09490 2127115..2127681 - 567 WP_041412608.1 site-specific integrase -
SHEWANA3_RS09495 2127790..2128197 - 408 WP_011716810.1 DUF2787 domain-containing protein -
SHEWANA3_RS09500 2128387..2128800 - 414 WP_011716811.1 DUF2787 domain-containing protein -
SHEWANA3_RS09505 2129045..2129401 - 357 WP_011716812.1 type IV toxin-antitoxin system YeeU family antitoxin -
SHEWANA3_RS09510 2129515..2129877 - 363 WP_011716813.1 hypothetical protein -
SHEWANA3_RS09515 2129918..2130424 - 507 WP_011716814.1 DNA repair protein RadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2121402..2141865 20463


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(7-44)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11169.71 Da        Isoelectric Point: 5.8404

>T21780 WP_011716806.1 NC_008577:c2125746-2125453 [Shewanella sp. ANA-3]
MPQIIFTATALRDLERLREFLRSKNPPATQRAASAIINTIRKLESYPDIGRPIDDNDFSFRELLIDFGDTGYLAMYQYDG
GERLTVLCIRHQKEAGY

Download         Length: 294 bp

>T21780 NC_008577:c2125746-2125453 [Shewanella sp. ANA-3]
ATGCCACAAATAATCTTCACCGCCACTGCATTACGTGATTTAGAGCGCTTACGTGAGTTTCTTCGCAGTAAAAATCCCCC
CGCCACACAACGCGCTGCCAGCGCCATAATCAATACCATTAGAAAACTGGAAAGCTATCCAGACATAGGCCGGCCTATCG
ATGACAATGACTTTAGCTTTAGGGAACTGCTCATTGACTTTGGTGACACAGGTTATTTGGCAATGTACCAGTATGATGGC
GGCGAACGATTGACCGTATTGTGTATACGCCACCAAAAAGAAGCTGGTTATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10955.25 Da        Isoelectric Point: 5.9920

>AT21780 WP_011716807.1 NC_008577:c2126018-2125734 [Shewanella sp. ANA-3]
MSTIKPVSVKLDADIKARVEHLAETRKRSSHWMMREAIREYVEREEKREALQQEALRAWEEHQTSGLHVTGDEVVSWLES
WGSENEQAAPTCHK

Download         Length: 285 bp

>AT21780 NC_008577:c2126018-2125734 [Shewanella sp. ANA-3]
ATGAGCACAATCAAACCCGTGTCGGTTAAATTAGATGCCGATATTAAAGCCAGAGTCGAGCATTTAGCCGAAACTCGTAA
ACGTTCATCACACTGGATGATGCGTGAAGCGATCCGTGAGTACGTTGAGAGAGAAGAGAAACGCGAGGCGTTGCAGCAAG
AAGCGTTACGTGCATGGGAAGAACACCAGACATCAGGCTTGCATGTGACTGGTGACGAAGTGGTGAGTTGGCTGGAGTCC
TGGGGAAGTGAAAATGAACAGGCTGCCCCTACATGCCACAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0KW60

Antitoxin

Source ID Structure
AlphaFold DB A0A448EM94

References