Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 2796232..2796865 Replicon chromosome
Accession NZ_CP083911
Organism Tepidimonas taiwanensis strain LMG 22826

Toxin (Protein)


Gene name vapC Uniprot ID A0A554XA78
Locus tag LCC91_RS13205 Protein ID WP_043701159.1
Coordinates 2796452..2796865 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A554XA73
Locus tag LCC91_RS13200 Protein ID WP_043701161.1
Coordinates 2796232..2796465 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCC91_RS13180 (LCC91_13180) 2791989..2793119 + 1131 WP_043701168.1 YbdK family carboxylate-amine ligase -
LCC91_RS13185 (LCC91_13185) 2793176..2794330 + 1155 WP_058615957.1 aminotransferase class V-fold PLP-dependent enzyme -
LCC91_RS13190 (LCC91_13190) 2794340..2795188 - 849 WP_052231587.1 ABC transporter permease -
LCC91_RS13195 (LCC91_13195) 2795210..2796151 - 942 WP_043701163.1 ATP-binding cassette domain-containing protein -
LCC91_RS13200 (LCC91_13200) 2796232..2796465 + 234 WP_043701161.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LCC91_RS13205 (LCC91_13205) 2796452..2796865 + 414 WP_043701159.1 PIN domain-containing protein Toxin
LCC91_RS13210 (LCC91_13210) 2796948..2797202 + 255 WP_043701158.1 helix-turn-helix transcriptional regulator -
LCC91_RS13215 (LCC91_13215) 2797253..2798122 + 870 WP_043701156.1 archaetidylserine decarboxylase -
LCC91_RS13220 (LCC91_13220) 2798229..2799743 - 1515 WP_043701154.1 AMP nucleosidase -
LCC91_RS13225 (LCC91_13225) 2799927..2801336 - 1410 WP_043701152.1 glutathione-disulfide reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-116)

Antitoxin

SpoVT-AbrB domain

(5-35)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14779.14 Da        Isoelectric Point: 4.5256

>T217790 WP_043701159.1 NZ_CP083911:2796452-2796865 [Tepidimonas taiwanensis]
MRAADVFLDTNVVLYLLSADARKADVAETLIQRGGTVSVQVLNEAAAVARRKLQMPLAEIREWLAAVRACCAVVPLTVAE
HDEALRLCERYALAFYDALIVAAALAAGAQVLYTEDLQPGLVIDGRLQVVNPFAVDN

Download         Length: 414 bp

>T217790 NZ_CP114801:c4307059-4306778 [Citrobacter sp. 21OH12SH02A-Citro]
ATGACCTATAACCTGGAGTTTTTAGATGTTGCGCTCAAGGAGTGGCGCAAGCTTTCACCCACATTACGCGAGCAGTTCAA
AAAGAAACTGGCGGAGCGGCTGGAAAATCCCCATGTCCCTGCCGCCCGCCTTTCCGGCAAATTACACCGTTACAAAATCA
AGCTTCGCAGTGCCGGGTATCGTCTGGTCTATCAGGTCGAGGACGAGCAGGTTGTCGTTCTTGTGATCGCAGTGGGCAGA
CGTGATGGTGATGAGGTTTATCATCAGGCTAACCGGCGCTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8754.12 Da        Isoelectric Point: 11.5284

>AT217790 WP_043701161.1 NZ_CP083911:2796232-2796465 [Tepidimonas taiwanensis]
VQVARWGNSLAIRLPVAVVRELGLREGDEIEIVALDRQRWGVHPAVTPVDALKALRRLRGRLPADFHFEREQIHARG

Download         Length: 234 bp

>AT217790 NZ_CP114801:c4307297-4307049 [Citrobacter sp. 21OH12SH02A-Citro]
ATGCCATTTCATATCCTGACCAAAACCGCTGCCAGTATCACCGACCTGAAACGTAACCCAATGGGGACAGTCAACGCCGG
GGAAGGTGAAGCGGTGGCGATTCTGAACCGCAATGAGCCTGCGTTTTACTGCGTGCCGCCTGCGGTCTATGCATATTTGC
TGGAGCTGGCTGAGGATGCCGAGCTGAACCGCATCGCCGACGAGCGAGAAGGTGGAAAGCGAATAAAGGTATCTTTAAAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A554XA78

Antitoxin

Source ID Structure
AlphaFold DB A0A554XA73

References