Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2649865..2650538 Replicon chromosome
Accession NZ_CP083911
Organism Tepidimonas taiwanensis strain LMG 22826

Toxin (Protein)


Gene name vapC Uniprot ID A0A554X781
Locus tag LCC91_RS12510 Protein ID WP_043700163.1
Coordinates 2650116..2650538 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A554X778
Locus tag LCC91_RS12505 Protein ID WP_043700160.1
Coordinates 2649865..2650119 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCC91_RS12485 (LCC91_12485) 2645134..2646216 - 1083 WP_043700326.1 extracellular solute-binding protein -
LCC91_RS12490 (LCC91_12490) 2646573..2647238 + 666 WP_052231493.1 LysE family transporter -
LCC91_RS12495 (LCC91_12495) 2647303..2648994 + 1692 WP_052231494.1 NAD(P)/FAD-dependent oxidoreductase -
LCC91_RS12500 (LCC91_12500) 2649045..2649770 + 726 WP_043700333.1 nitrilase-related carbon-nitrogen hydrolase -
LCC91_RS12505 (LCC91_12505) 2649865..2650119 + 255 WP_043700160.1 plasmid stabilization protein Antitoxin
LCC91_RS12510 (LCC91_12510) 2650116..2650538 + 423 WP_043700163.1 type II toxin-antitoxin system VapC family toxin Toxin
LCC91_RS12515 (LCC91_12515) 2650603..2651550 - 948 WP_043700167.1 LysR family transcriptional regulator -
LCC91_RS12520 (LCC91_12520) 2651698..2653923 + 2226 WP_043700169.1 malate synthase G -
LCC91_RS12525 (LCC91_12525) 2653920..2654882 - 963 WP_224440951.1 diguanylate cyclase -
LCC91_RS12530 (LCC91_12530) 2655294..2655386 + 93 WP_224440952.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15045.53 Da        Isoelectric Point: 6.2148

>T217789 WP_043700163.1 NZ_CP083911:2650116-2650538 [Tepidimonas taiwanensis]
MILLDTNVVSEPLRPTPATRVIDWLDQQPLETLHLSVMTVAELRAGVALLPVGRRRAQLHDAVETQLLPSFAGRVLPFDL
ACTSAYARVLAAAREAGCAIATADVCIAAVALTHGLIVATRDVRPFRTVGLTVINPWEEG

Download         Length: 423 bp

>T217789 NZ_CP114801:c4186884-4186597 [Citrobacter sp. 21OH12SH02A-Citro]
ATGCCAATGGAGTTTGAGTGGGATGCAAACAAGGCACAAAGTAACCTGAGGAAACATGGTGTTCGCTTTGAGGACGCAAT
ATTGGTTTTCGACGATCCCCAACATCTGTCGCGGCAGGAGCGGTATGAGAACGGTGAGTATCGCTGGCAGACCATTGGTC
TCGTTCATGGCATTGTGGTTATTCTGGTTGCCCATAGCGTTAGGTTTGAAAGTGGCTTTGAAGTCATTCGTATCATCAGC
GCCAGAAAGGCAGATCGTAAAGAGAGGAATCGTTATGAGCATAGTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9212.49 Da        Isoelectric Point: 11.5284

>AT217789 WP_043700160.1 NZ_CP083911:2649865-2650119 [Tepidimonas taiwanensis]
MPSVTIRHVPDEVHRAIRVRAAQHGRSAEAEMRAILEAAVRPSNRLKLGSLLAAAGRQVGLTEEEFRVLQSARDQTPARA
ASFE

Download         Length: 255 bp

>AT217789 NZ_CP114801:c4186610-4186308 [Citrobacter sp. 21OH12SH02A-Citro]
ATGAGCATAGTTAAACATAAACGCGGCAGCGTATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
TAAACCGGACGATGATATCGATTACAGCGACATTCCCGTGACCGAAGATAAGCAGTGGTCAGAGGCCATTCGCGGTAAGT
TTTTTCGTCCGTTAAAAACGCAGGCGTCGGTGCGCATTGATGCCGATGTGATGGAATGGCTGAAGCGCCCCGGGAAGGGT
TACCAGACGCGTCTCAATGCCATTTTGCGCGAAGCGATGCTGCGCGAGCAAAACAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A554X781

Antitoxin

Source ID Structure
AlphaFold DB A0A554X778

References