Detailed information of TA system TA217785

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1792751..1793346
• Replicon: chromosome
• Accession: NZ_CP083911
• Organism: Tepidimonas taiwanensis strain LMG 22826

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LCC91_RS08405
• Protein ID: WP_224440891.1
• Coordinates: 1793083..1793346 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A554X2A5
• Locus tag: LCC91_RS08400
• Protein ID: WP_043698593.1
• Coordinates: 1792751..1793086 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCC91_RS08395 (LCC91_08395)	1789132..1790091	+	960	WP_224440890.1	IS481 family transposase	-
LCC91_RS08400 (LCC91_08400)	1792751..1793086	-	336	WP_043698593.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LCC91_RS08405 (LCC91_08405)	1793083..1793346	-	264	WP_224440891.1	type II toxin-antitoxin system HicA family toxin	Toxin
LCC91_RS08410 (LCC91_08410)	1793535..1794128	-	594	WP_043698653.1	DUF3501 family protein	-
LCC91_RS08415 (LCC91_08415)	1794228..1795577	-	1350	WP_043698588.1	heterodisulfide reductase-related iron-sulfur binding cluster	-
LCC91_RS08420 (LCC91_08420)	1795754..1796176	-	423	WP_043698586.1	rubrerythrin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1789132..1790091	959

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (26-76)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9886.54 Da
• Isoelectric Point: 11.0310

>T217785 WP_224440891.1 NZ_CP083911:c1793346-1793083 [Tepidimonas taiwanensis]
MLRMHSRHRKTLEAIFAKPTSATIEWSRIEALLIAVGCTVIEGRGSRVRFAFGDKVATFHRPHPAKEAKPYQVEDARTFL
ERIGVKP

Nucleotide

• Length: 264 bp

>T217785 NZ_CP114801:2347115-2347303 [Citrobacter sp. 21OH12SH02A-Citro]
GTGAAGCAAAGTGAGTTCAGACGCTGGCTTGAATCTCAGGGAGTGGCTGTTACAAACGGCTCAAATCATCTGAAGTTGAG
GTATCAGGGAAGGCGTAGCGTTATGCCCAGGCATCCTGGTGATGAAATAAAAGAAGCCTTGCGAAAATCGATCCTGAAGC
AGCTTGGCTTACAGTCATCATCAATATGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 11997.66 Da
• Isoelectric Point: 6.2186

>AT217785 WP_043698593.1 NZ_CP083911:c1793086-1792751 [Tepidimonas taiwanensis]
MNTMTYKGYTARIEFDDRDNILVGRLLGIQDIVSFHADNVADLRTAFEEAVDDYLETCAKLGKKPEKPASGRLMLRVPPE
VHSAALVAAQAAGTSLNQWAAKVLAQAAHAG

Nucleotide

• Length: 336 bp

>AT217785 NZ_CP114801:2347335-2347751 [Citrobacter sp. 21OH12SH02A-Citro]
ATGCGTTATCCCGTTAATCTAATCCCCGCCGTGGAAGGTGGATTCGTGGTTTCTTTCCCGGATATTCCTGAAGCATTAAC
CCAGGGCGAAACCCGTCATGGGGCTTTGCAGGCTGCGCAGTCTGCATTGGTGACCGCTTTTGAATTCTATTTCGACGATA
ACGAACCGATTCCTTTACCTTCGGCGGTTGGCACTGAAGGTGACTATGTGGAAATCCCCCTGAGCATTGCGTCGAAGGTT
CTTTTGTTAAATGCCTTTCTTGAATCAAAAATCACCCAGCAGGAGCTGGCAAACAGGATTGGCAGGCCTAAGCAGGAAAT
TACCCGTTTGTTCGATTTAAAGCACGCGACAAAAATTGATGCTGTGCAAATAGCTGCACGCGCCTTAGGCAAGGAGCTGT
CAGTAACGATGTTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A554X2A5