Detailed information of TA system TA217784

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 1711321..1711979
• Replicon: chromosome
• Accession: NZ_CP083911
• Organism: Tepidimonas taiwanensis strain LMG 22826

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LCC91_RS08045
• Protein ID: WP_143897548.1
• Coordinates: 1711566..1711979 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A554XAS9
• Locus tag: LCC91_RS08040
• Protein ID: WP_043700651.1
• Coordinates: 1711321..1711569 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCC91_RS08025 (LCC91_08025)	1706736..1707971	-	1236	WP_043700649.1	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	-
LCC91_RS08030 (LCC91_08030)	1707989..1710745	-	2757	WP_043700650.1	preprotein translocase subunit SecA	-
LCC91_RS08035 (LCC91_08035)	1710888..1711211	-	324	WP_052231543.1	DciA family protein	-
LCC91_RS08040 (LCC91_08040)	1711321..1711569	+	249	WP_043700651.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LCC91_RS08045 (LCC91_08045)	1711566..1711979	+	414	WP_143897548.1	type II toxin-antitoxin system VapC family toxin	Toxin
LCC91_RS08050 (LCC91_08050)	1711998..1713074	-	1077	WP_224440886.1	PQQ-dependent sugar dehydrogenase	-
LCC91_RS08055 (LCC91_08055)	1713209..1716088	-	2880	WP_143897546.1	DEAD/DEAH box helicase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-62)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15093.38 Da
• Isoelectric Point: 8.6180

>T217784 WP_143897548.1 NZ_CP083911:1711566-1711979 [Tepidimonas taiwanensis]
MSYLIDTNVLSELRRRSPDPGVAAWFAQRPATTLYVSVLTLGEIRKGIEGVTDDRRRQALLDWLETDLPAFFTGRVLPID
RAVADRWGRLVAAAGRPLPAIESLLAATALTHDLVLVTRNSKDFAGLPVVTLNPWST

Nucleotide

• Length: 414 bp

>T217784 NZ_CP114801:851785-852192 [Citrobacter sp. 21OH12SH02A-Citro]
GTGGTCCAGTGGCAATCTGATTTACGCGTTTCATGGCGCGCGCAATGGCTTTCGCTGCTCATTCATGGGCTGGTCGCGGT
ATTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTCTGCTCTCTCTGGTGGTGTTCGATAGCG
TCCGTAGCCAGCGCCGAATCAATGCCTGTCAGGGCGAGATTCGGCTGTTGATGGACGGTCGTCTGCGCTGGCAAGGGCAA
GAGTGGACTATTGCTAGCGCACCCTGGATGGTCAAAACAGGCATGATGCTGCGTTTACGTTCCGATGCCGGAAAACGTCA
GCATTTGTGGCTGGCGGCAGACAGTATGGATGACGCGGAGTGGCGGGATTTGCGGCGGTTAATACTGCAACAGGCGAAGC
AGGGATAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9403.74 Da
• Isoelectric Point: 5.8369

>AT217784 WP_043700651.1 NZ_CP083911:1711321-1711569 [Tepidimonas taiwanensis]
MQTWQMQQAKARLSELVKCAREQPQAITVHGEPVAIVVSRETFERLAQASESLLDFMRRSPLYGEEDIAFARDPSRTREV
VL

Nucleotide

• Length: 249 bp

>AT217784 NZ_CP114801:851538-851804 [Citrobacter sp. 21OH12SH02A-Citro]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGTCGCGGTATGCGTGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGATGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGACT
TATTTAACTGGTTGATGAATCATGGGAAACCGGCTGATGCTCAGCTAGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A554XAS9