Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1568391..1569022 Replicon chromosome
Accession NZ_CP083911
Organism Tepidimonas taiwanensis strain LMG 22826

Toxin (Protein)


Gene name vapC Uniprot ID A0A554XC25
Locus tag LCC91_RS07245 Protein ID WP_043700878.1
Coordinates 1568621..1569022 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A554XBZ3
Locus tag LCC91_RS07240 Protein ID WP_043700875.1
Coordinates 1568391..1568624 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCC91_RS07220 (LCC91_07220) 1563638..1564369 - 732 WP_043700538.1 GTP cyclohydrolase I -
LCC91_RS07225 (LCC91_07225) 1564480..1566135 + 1656 WP_143897426.1 AAA-like domain-containing protein -
LCC91_RS07230 (LCC91_07230) 1566262..1567500 - 1239 WP_043700871.1 cardiolipin synthase ClsB -
LCC91_RS07235 (LCC91_07235) 1567497..1568258 - 762 WP_043700873.1 endonuclease/exonuclease/phosphatase family protein -
LCC91_RS07240 (LCC91_07240) 1568391..1568624 + 234 WP_043700875.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LCC91_RS07245 (LCC91_07245) 1568621..1569022 + 402 WP_043700878.1 type II toxin-antitoxin system VapC family toxin Toxin
LCC91_RS07250 (LCC91_07250) 1568952..1569479 - 528 WP_082007573.1 dihydroneopterin triphosphate diphosphatase -
LCC91_RS07255 (LCC91_07255) 1569526..1570215 - 690 WP_043700880.1 glycosyl transferase -
LCC91_RS07260 (LCC91_07260) 1570229..1570684 - 456 WP_185974860.1 hypothetical protein -
LCC91_RS07265 (LCC91_07265) 1570712..1573012 + 2301 WP_185974861.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14583.89 Da        Isoelectric Point: 7.2763

>T217783 WP_043700878.1 NZ_CP083911:1568621-1569022 [Tepidimonas taiwanensis]
MILLDTNICIYLINRKPPAVLQRFRAYRAGEIGLSSIVAAELAYGVAKSGSARNQQALELFLAPLEIHPFDTQAIWVYGR
LRATLEQQGTPIGAMDTLIAAHALALDATLVTHNTREFARVPGLRLEDWALAS

Download         Length: 402 bp

>T217783 NZ_CP114801:64997-65338 [Citrobacter sp. 21OH12SH02A-Citro]
ATGTGGGAAGTGGAAACAACGGATGTTTTCGATAAATGGTTTGACGTACAGACCGAGGCGCTCAAGGAAGATATGCTCGC
AGCGATGATGATTTTATCCGAGTATGGTCCTCAGTTAGGCAGGCCGTTTGCTGATACGGTAAATGCTTCTGCTTTTTCAA
ATATGAAAGAGTTGCGAGTGCAGCATCAGGGCAACCCGATTCGGGCGTTCTTCGTGTTTGATCCTTCTCGCCATGGCATC
GTGTTATGCGCAGGCGATAAAACAGGGTTAAACGAGAAGAAATTCTATAAAGAGATGATCAGGCTTGCTGACGCTGAGTA
CCGAAATCACCTTAATAAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8685.02 Da        Isoelectric Point: 8.7092

>AT217783 WP_043700875.1 NZ_CP083911:1568391-1568624 [Tepidimonas taiwanensis]
METAKLFTTGRSQAVRLPKPYRFHGREVGIRRVGAGILLFPVDDPWSVLEQALDLFEPGFELKRDQPPPQARPEIAA

Download         Length: 234 bp

>AT217783 NZ_CP114801:65347-65646 [Citrobacter sp. 21OH12SH02A-Citro]
ATGGCGACGCTTAAAGAATTGATGGCGAAACAAAGCCCGGAAAGCCAGGAGCGCATTGCTGAAAAAGTAGAAGTGCTACG
TCAGGTGATTGCGTTAAATATGTTACGGGAAGAACTGAATCTCTCTCAGGCGGAACTTGCCTCGGCAATGGGCGTTAAGC
AGCCAACAATCGCAAAAATGGAACAGGCGGATAACGATCCTCGTCTGTCGACGCTTAAGCGTTATGTCACAGCGTTAGGT
GGCGAACTGAGCATTGATGTTAAGTTACCGACAGGTAAAAGAGTCGCGTTTCATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A554XC25

Antitoxin

Source ID Structure
AlphaFold DB A0A554XBZ3

References