Detailed information of TA system TA217781

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 824806..825326
• Replicon: chromosome
• Accession: NZ_CP083911
• Organism: Tepidimonas taiwanensis strain LMG 22826

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A0A554X6R3
• Locus tag: LCC91_RS03815
• Protein ID: WP_043699967.1
• Coordinates: 825000..825326 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: LCC91_RS03810
• Protein ID: WP_224441012.1
• Coordinates: 824806..825003 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCC91_RS03800 (LCC91_03800)	820270..821511	+	1242	WP_224441011.1	efflux RND transporter periplasmic adaptor subunit	-
LCC91_RS03805 (LCC91_03805)	821539..824622	+	3084	WP_043699962.1	efflux RND transporter permease subunit	-
LCC91_RS03810 (LCC91_03810)	824806..825003	+	198	WP_224441012.1	antitoxin MazE family protein	Antitoxin
LCC91_RS03815 (LCC91_03815)	825000..825326	+	327	WP_043699967.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
LCC91_RS03820 (LCC91_03820)	825390..827231	-	1842	WP_043699969.1	PhoH family protein	-
LCC91_RS03825 (LCC91_03825)	827332..827808	-	477	WP_043699973.1	peroxiredoxin	-
LCC91_RS03830 (LCC91_03830)	827966..828346	-	381	WP_043699978.1	Mth938-like domain-containing protein	-
LCC91_RS03835 (LCC91_03835)	828422..829657	+	1236	WP_143897919.1	pyridoxal phosphate-dependent aminotransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-105)

Antitoxin

• Antitoxin MazE-like (1-63)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 11700.84 Da
• Isoelectric Point: 8.0546

>T217781 WP_043699967.1 NZ_CP083911:825000-825326 [Tepidimonas taiwanensis]
MKRGDLVTIAMQGDFGKPRPALVIQADLFGELDSVTVLPLTSTLVEAPLLRVMVQPSADNGLHRPSQVMIDKAVTVRRDK
LGPAFGHLDANILIQVERCLAIFLGIAK

Nucleotide

• Length: 327 bp

>T217781 NZ_CP114796:3553817-3554020 [Providencia sp. 21OH12SH02B-Prov]
ATGACCAAAACTGATTATCTGATGCGTTTAAGAAAATGCACAACCATCGATACACTTGAGCGTGTTATTGAAAAAAATAA
GTATGAGCTTTCTGAAGACGAGCTGGAACTATTTTACTCAGCCGCAGATCACCGTCTTGCAGAACTCACTATGAATAAAC
TTTATGACAAAATTCCAGCCTCTGTTTGGAAATTTGTTAGATAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7548.55 Da
• Isoelectric Point: 11.0656

>AT217781 WP_224441012.1 NZ_CP083911:824806-825003 [Tepidimonas taiwanensis]
MQKHRRQMRQAGFRLVQIWVPDTRRPDFAQECRRQGLRVAQADRADTQLHTLMDAAAADVDGWTA

Nucleotide

• Length: 198 bp

>AT217781 NZ_CP114796:3553370-3553738 [Providencia sp. 21OH12SH02B-Prov]
ATGGATGAATATTCACCCAAAAATTATGATATATCAGAGTTAAAATACTTGTGTAACAGTTTGAATAGAGAAGCAATTTC
AAGCTTACAGAAAACAAATACACATTGGATAAATGATTTAAGCTCACCACAAAGTGTACGGCTCAATGAGCTTATTGAAC
ATATAGCCGCCTTTGTATGGCAATATAAGATCAAACATCCAAAAGATAATCTCGTTATATCATTAGTAGAAGAGTATCTT
GACGAGACTTACGATTTATTCGGTAGTCCGGTAATAACGTTAAGTGAAATTATTGACTGGCAGAGTATGAATCAAAATCT
TGTCGCTGTACTTGATGATGATTTAAAATGCCCTGCAAGCAAGACCTAA

Structures

Toxin

• AlphaFold DB: A0A554X6R3