Detailed information of TA system TA217779

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 19130..19622
• Replicon: plasmid pZM33
• Accession: NZ_CP083901
• Organism: Zymomonas mobilis strain ZM481

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: LB319_RS09595
• Protein ID: WP_062339561.1
• Coordinates: 19130..19414 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: LB319_RS09600
• Protein ID: WP_062339563.1
• Coordinates: 19398..19622 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LB319_RS09580 (LB319_09580)	16952..18074	-	1123	Protein_16	transposase	-
LB319_RS09585 (LB319_09585)	18231..18590	+	360	WP_237332005.1	IS5 family transposase	-
LB319_RS09590 (LB319_09590)	18554..18799	+	246	WP_224453022.1	transposase	-
LB319_RS09595 (LB319_09595)	19130..19414	-	285	WP_062339561.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LB319_RS09600 (LB319_09600)	19398..19622	-	225	WP_062339563.1	TraY domain-containing protein	Antitoxin
LB319_RS09605 (LB319_09605)	19965..21470	-	1506	WP_062339565.1	helix-turn-helix domain-containing protein	-
LB319_RS09610 (LB319_09610)	21577..21828	-	252	WP_062339567.1	DUF2312 domain-containing protein	-
LB319_RS09615 (LB319_09615)	21953..22270	-	318	WP_062339569.1	hypothetical protein	-
LB319_RS09620 (LB319_09620)	22674..23162	+	489	WP_062339571.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..33006	33006

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Relaxosome protein TraY (4-49)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10895.82 Da
• Isoelectric Point: 10.9192

>T217779 WP_062339561.1 NZ_CP083901:c19414-19130 [Zymomonas mobilis]
MAWKIEFDPAAQKELKKLGTQPAKRILRFLSERLALADDPRSFGAALKGTTLGNLWKYRIGDYRIIADIEDNVMRILVVR
IGNRREIYKKAVRH

Nucleotide

• Length: 285 bp

>T217779 NZ_CP114791:4417371-4417913 [Sphingomonas sp. NIBR02145]
TTGGGAGTAATTGAGCCACTCGGCGCCCCCAGACCAGCTTACGCGGCACCGACGCCAATCACCGCAGACCATCGACTGGA
CGGCTTCGAGTGCGGCAAGCCGCCGCTCGACAGTTGGCTCAAGACCCATGCCCTCGACAATGAAGGCAAGGCGTCCCGGA
CCTATGTCGTCGATGCCAGGCTAGGCGAGGATGCCGGCAATGTAGTTGCGTATTACACGCTCGCCTTTGGAAGCGTCACG
CGCGAAGAGGTGCCGAAGAAGATTCGTCAAGGCTTGCCCAATCCCGTTCCAGTGATGGTGCTGGGCCGTCTCGCAGTCGA
CAAACGCCATGCTGGCAAGGGATTAGGGCCGGCGCTCCTTCGCGAGGCCTTGCAGCGAACCGCGGAAGCTTCGCGCATTG
GTGGGCTTCGCGCCTTAATCGTCCATGCGATCGATGATGACGCCGTGAGCTTCTACACCAAGTACGGCTTCCAGATTTTT
CCAGCGGGCTCCAGGACCTTGTTCCTGCCTATCGAAACGGTGCGCCAAAGCATCGTTGAATGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8398.60 Da
• Isoelectric Point: 4.8172

>AT217779 WP_062339563.1 NZ_CP083901:c19622-19398 [Zymomonas mobilis]
MLAIRLPEEIEDRLSALANATGRTKTFYAREAILHHLEELEDIYLAEARAVKIRSGQTKTVPLENIMAEYGLEN

Nucleotide

• Length: 225 bp

>AT217779 NZ_CP114791:4417096-4417380 [Sphingomonas sp. NIBR02145]
ATGGCCAGCGTAGCGGAACGGCCGAAGGCCGATACATCGATCACGATGCGTTTGCCCGTGCAGACGCGCGACCTCATCGA
TCGCGCGGCCGCGACCATCGATAAATCACGCACCGAGTTCGTGCTCGAGAGCGCTCGACAGCGTGCGATCGATGTACTGC
TGGATCAGCGCGTTTTCCATCTCGATGCCGAGGCGAGCGATGCCCTTGCCGATGTCCTTGAAAACCCGCCAGCGCCGGTC
GACGCGCTGCGCAAGCTGATGGCGAGCAAGTCGCCTTGGGAGTAA