Detailed information of TA system TA217762

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 4442113..4443038
• Replicon: chromosome
• Accession: NZ_CP083888
• Organism: Escherichia coli strain NDM1

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: LCE25_RS21495
• Protein ID: WP_014640052.1
• Coordinates: 4442113..4442499 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: LCE25_RS21500
• Protein ID: WP_001339382.1
• Coordinates: 4442529..4443038 (-)
• Length: 170 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCE25_RS21450 (4437809)	4437809..4438171	+	363	WP_000135680.1	protein YfdP	-
LCE25_RS21455 (4438237)	4438237..4439061	+	825	WP_224446591.1	DUF2303 family protein	-
LCE25_RS21460 (4439189)	4439189..4439725	+	537	WP_000008165.1	5'-deoxynucleotidase	-
LCE25_RS21465 (4439716)	4439716..4440219	+	504	WP_224446592.1	ead/Ea22-like family protein	-
LCE25_RS21470 (4440221)	4440221..4440412	+	192	WP_021518174.1	hypothetical protein	-
LCE25_RS21475 (4440414)	4440414..4440962	+	549	WP_114447249.1	DUF551 domain-containing protein	-
LCE25_RS21480 (4440962)	4440962..4441534	+	573	WP_001061339.1	3'-5' exonuclease	-
LCE25_RS21485 (4441571)	4441571..4441852	+	282	WP_224446593.1	pyocin activator PrtN family protein	-
LCE25_RS21490 (4441900)	4441900..4442073	-	174	WP_000390071.1	hypothetical protein	-
LCE25_RS21495 (4442113)	4442113..4442499	-	387	WP_014640052.1	hypothetical protein	Toxin
LCE25_RS21500 (4442529)	4442529..4443038	-	510	WP_001339382.1	Panacea domain-containing protein	Antitoxin
LCE25_RS21505 (4443355)	4443355..4443459	-	105	Protein_4200	tRNA-dihydrouridine synthase	-
LCE25_RS21510 (4443823)	4443823..4444844	-	1022	Protein_4201	DUF2713 domain-containing protein	-
LCE25_RS21515 (4445162)	4445162..4445677	+	516	WP_001295691.1	zinc uptake transcriptional repressor Zur	-
LCE25_RS21520 (4445719)	4445719..4445928	-	210	WP_001030593.1	CsbD family protein	-
LCE25_RS21525 (4446044)	4446044..4447369	-	1326	WP_001295692.1	MATE family efflux transporter DinF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4395831..4448528	52697

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (6-116)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T217762 WP_014640052.1 NZ_CP083888:c4442499-4442113 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T217762 NZ_CP114771:5209700-5210116 [Endozoicomonas sp. GU-1]
GTGTATTTGATTGATACCAATGTCATTGGTGAAATTCGCAAGAAACAAAAAGCCAACCCCGGTGTTCAGGGGTTCTTTAA
AGAGGCGACTCAACAGGCATCGCCACTCTATCTCAGCGTGATTACCCTCGGAGACCTCCGTCGGGGTGTGGAGAAAATTC
GCCATAGAGGTGACACGCCTCAGGCCAAGCAGCTTGAACACTGGCTGAAGACCCTGATCAGAGACTACAGCCAGTACATC
CTGGAATTTGGCATTACCGAGGCTCAAATCTGGGGGAAGCTCAGAGTGCCTTATGAAAATGCCATTGAGAAACAAATTGC
GGCCACAGCCATCACCTATGGCCTGACACTGGTTACCCGCAACACCCGGGCCTTTATCAATACGGGGGTAAACGTTTTAA
ATCCATTCTGGAATTGA

Antitoxin

Protein

• Length: 170 a.a.
• Molecular weight: 19576.29 Da
• Isoelectric Point: 5.3338

>AT217762 WP_001339382.1 NZ_CP083888:c4443038-4442529 [Escherichia coli]
MAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHNVSLRSDPREMDAD
EVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Nucleotide

• Length: 510 bp

>AT217762 NZ_CP114771:5209480-5209713 [Endozoicomonas sp. GU-1]
GTGCCTAACCTAATCGTTCGTAATATTGACGAAAAAATCGTTGCAGCACTTAAGGCTCAAGCGGGTAAAAATGGGCTTAG
CGCAGAGGCCGAACACCGTCGGATTCTTGAATCGGTTCTGTTAAAGCCCCAAAAAAAGAGCTTTACTGAAGCCCTGAAAA
GTATCCCCAATGTAGGTAATGATGATGACTTTGAGCGTCTCGAAGACAGTGGTGATTCCAGTGTATTTGATTGA