Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4442113..4443038 Replicon chromosome
Accession NZ_CP083888
Organism Escherichia coli strain NDM1

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag LCE25_RS21495 Protein ID WP_014640052.1
Coordinates 4442113..4442499 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag LCE25_RS21500 Protein ID WP_001339382.1
Coordinates 4442529..4443038 (-) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCE25_RS21450 (4437809) 4437809..4438171 + 363 WP_000135680.1 protein YfdP -
LCE25_RS21455 (4438237) 4438237..4439061 + 825 WP_224446591.1 DUF2303 family protein -
LCE25_RS21460 (4439189) 4439189..4439725 + 537 WP_000008165.1 5'-deoxynucleotidase -
LCE25_RS21465 (4439716) 4439716..4440219 + 504 WP_224446592.1 ead/Ea22-like family protein -
LCE25_RS21470 (4440221) 4440221..4440412 + 192 WP_021518174.1 hypothetical protein -
LCE25_RS21475 (4440414) 4440414..4440962 + 549 WP_114447249.1 DUF551 domain-containing protein -
LCE25_RS21480 (4440962) 4440962..4441534 + 573 WP_001061339.1 3'-5' exonuclease -
LCE25_RS21485 (4441571) 4441571..4441852 + 282 WP_224446593.1 pyocin activator PrtN family protein -
LCE25_RS21490 (4441900) 4441900..4442073 - 174 WP_000390071.1 hypothetical protein -
LCE25_RS21495 (4442113) 4442113..4442499 - 387 WP_014640052.1 hypothetical protein Toxin
LCE25_RS21500 (4442529) 4442529..4443038 - 510 WP_001339382.1 Panacea domain-containing protein Antitoxin
LCE25_RS21505 (4443355) 4443355..4443459 - 105 Protein_4200 tRNA-dihydrouridine synthase -
LCE25_RS21510 (4443823) 4443823..4444844 - 1022 Protein_4201 DUF2713 domain-containing protein -
LCE25_RS21515 (4445162) 4445162..4445677 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
LCE25_RS21520 (4445719) 4445719..4445928 - 210 WP_001030593.1 CsbD family protein -
LCE25_RS21525 (4446044) 4446044..4447369 - 1326 WP_001295692.1 MATE family efflux transporter DinF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4395831..4448528 52697


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T217762 WP_014640052.1 NZ_CP083888:c4442499-4442113 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T217762 NZ_CP114771:5209700-5210116 [Endozoicomonas sp. GU-1]
GTGTATTTGATTGATACCAATGTCATTGGTGAAATTCGCAAGAAACAAAAAGCCAACCCCGGTGTTCAGGGGTTCTTTAA
AGAGGCGACTCAACAGGCATCGCCACTCTATCTCAGCGTGATTACCCTCGGAGACCTCCGTCGGGGTGTGGAGAAAATTC
GCCATAGAGGTGACACGCCTCAGGCCAAGCAGCTTGAACACTGGCTGAAGACCCTGATCAGAGACTACAGCCAGTACATC
CTGGAATTTGGCATTACCGAGGCTCAAATCTGGGGGAAGCTCAGAGTGCCTTATGAAAATGCCATTGAGAAACAAATTGC
GGCCACAGCCATCACCTATGGCCTGACACTGGTTACCCGCAACACCCGGGCCTTTATCAATACGGGGGTAAACGTTTTAA
ATCCATTCTGGAATTGA

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19576.29 Da        Isoelectric Point: 5.3338

>AT217762 WP_001339382.1 NZ_CP083888:c4443038-4442529 [Escherichia coli]
MAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHNVSLRSDPREMDAD
EVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp

>AT217762 NZ_CP114771:5209480-5209713 [Endozoicomonas sp. GU-1]
GTGCCTAACCTAATCGTTCGTAATATTGACGAAAAAATCGTTGCAGCACTTAAGGCTCAAGCGGGTAAAAATGGGCTTAG
CGCAGAGGCCGAACACCGTCGGATTCTTGAATCGGTTCTGTTAAAGCCCCAAAAAAAGAGCTTTACTGAAGCCCTGAAAA
GTATCCCCAATGTAGGTAATGATGATGACTTTGAGCGTCTCGAAGACAGTGGTGATTCCAGTGTATTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References