Detailed information of TA system TA217760

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4092558..4093372
• Replicon: chromosome
• Accession: NZ_CP083888
• Organism: Escherichia coli strain NDM1

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: LCE25_RS19705
• Protein ID: WP_001054376.1
• Coordinates: 4092558..4092815 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: LCE25_RS19710
• Protein ID: WP_001309181.1
• Coordinates: 4092827..4093372 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCE25_RS19680 (4087846)	4087846..4088952	+	1107	WP_023568191.1	N-acetylneuraminate epimerase	-
LCE25_RS19685 (4089017)	4089017..4089997	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
LCE25_RS19690 (4090107)	4090107..4090312	+	206	Protein_3842	HNH endonuclease	-
LCE25_RS19695 (4090580)	4090580..4091820	-	1241	Protein_3843	helicase YjhR	-
LCE25_RS19700 (4091936)	4091936..4092067	+	132	WP_001309182.1	hypothetical protein	-
LCE25_RS19705 (4092558)	4092558..4092815	+	258	WP_001054376.1	YjhX family toxin	Toxin
LCE25_RS19710 (4092827)	4092827..4093372	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
LCE25_RS19715 (4093428)	4093428..4094174	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
LCE25_RS19720 (4094343)	4094343..4094561	+	219	Protein_3848	hypothetical protein	-
LCE25_RS19725 (4094599)	4094599..4094715	+	117	Protein_3849	VOC family protein	-
LCE25_RS19730 (4094960)	4094960..4096081	+	1122	WP_000010829.1	M42 family metallopeptidase	-
LCE25_RS19735 (4096078)	4096078..4096356	+	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
LCE25_RS19740 (4096368)	4096368..4097681	+	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimI / fimA / fimE	4081568..4101596	20028

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T217760 WP_001054376.1 NZ_CP083888:4092558-4092815 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T217760 NZ_CP114771:3485438-3485707 [Endozoicomonas sp. GU-1]
ATGACCGATAAGCACCGACTGCTTTGCTGGTCACACAATGCCTGGAACGATTACCTGTACTGGCAGGAGCAGGACCGGAA
AACCCTGAAGCGCATCAATAAACTAATAACCGAGTGTCTGCGCGACCCATTTAAGGGTATTGGCAAACCCGAGCCGCTGA
AAGGTAACTGGCAGGGGTTCTGGTCACGGCGGATCAGCGATGAACACCGGCTGGTCTATCAGGCCACAGATGCCCGACTG
ATCATTGCTGCCTGCCGGTTTCACTACTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT217760 WP_001309181.1 NZ_CP083888:4092827-4093372 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT217760 NZ_CP114771:3485191-3485448 [Endozoicomonas sp. GU-1]
ATGAAAGTCGTGTCCTATTCCGAAGCCCGGAACAATCTGAAATCCGTTCTTGATCAGGTGGCAGAGGATGCCAGTGAAAC
CCTGATTCATCGCCGTGACGGTCAGGATGCTGTTGTAATGTCGCTGGACAGCTACAACAGCCTGATGGAAACCCTGCACC
TGATGTCATCCCCGGCCAACGCCCAACACCTGAACGACTCCATTGAGCAGATCAGGACCGGGCAGGTCATGGAACGGGGA
TTGCTGGATGACCGATAA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8