Detailed information of TA system TA217758

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2380469..2382057
• Replicon: chromosome
• Accession: NZ_CP083888
• Organism: Escherichia coli strain NDM1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: F4NFZ0
• Locus tag: LCE25_RS11520
• Protein ID: WP_001125463.1
• Coordinates: 2380735..2382057 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LCE25_RS11515
• Protein ID: WP_001296726.1
• Coordinates: 2380469..2380735 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCE25_RS11515 (2380469)	2380469..2380735	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LCE25_RS11520 (2380735)	2380735..2382057	+	1323	WP_001125463.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
LCE25_RS11525 (2382369)	2382369..2382577	+	209	Protein_2249	AraC family transcriptional regulator	-
LCE25_RS11530 (2383009)	2383009..2383572	+	564	WP_001296758.1	type 1 fimbrial major subunit FimA	-
LCE25_RS11535 (2383933)	2383933..2384643	+	711	WP_001195166.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimA	2380469..2396557	16088

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49422.05 Da
• Isoelectric Point: 9.1203

>T217758 WP_001125463.1 NZ_CP083888:2380735-2382057 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T217758 NZ_CP114771:3438910-3439197 [Endozoicomonas sp. GU-1]
ATGAGCAGGAAGCTAAAGACCTTTGATGCATCAGAGTATCTTGACGACAGTGAAACTATTGCAGAGTACTTGAATGCAGT
CATCGAAACGGGTGACCAAGCTTTGCTCTTATCGGCTATTGGTGATATCGCCAAGGCAACAGGGATGCAGAAGATAGCCA
ATGACTCAGGCCTCGGTCGGGAAAGTTTATACAAAGCCCTGGCACCAGGTGCGAAACCAAGATTTGATACAGTGTTCAAA
ATTCTTCAGGCCCTGGGAGTGAGTTTGAAAATCAGCCCTCAGCATTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT217758 WP_001296726.1 NZ_CP083888:2380469-2380735 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT217758 NZ_CP114771:3438531-3438908 [Endozoicomonas sp. GU-1]
ATGAAAGACCTGACCCCCGGTTTTTTTCCGTTTTTTGTGTGTGAACTTGAATATGTATCCAAATGGATACATAATTCCTT
AATGTACTTGCTCAAGACCACTGACCACTTCGAGAAGTGGCTGCACAAACTTAAAGACAAGCAGGGCAAGGCTCGAATCC
TGGCCTCTCTTAAATTGCTGGAGCAGGGACACATCGGGGACTGGAAATCAGTTGGAGGCAAAGTGTCAGAACTTCGGGTG
CACTACGGGGCAGGCTATAGGATCTACTTTGCCAGGCAAGAGGATGTCATCATCGTATTACTCAATGGTGGTGACAAGGC
CAGCCAGTCCAGAGACATTGAAAAAGCAAAAGCCATTTTAAAAAATCTGGAGGCATGA

Structures

Toxin

• AlphaFold DB: A0A7U9IYX0