Detailed information of TA system TA021774

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 831684..832695
• Replicon: chromosome
• Accession: NC_008576
• Organism: Magnetococcus marinus MC-1

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: MMC1_RS03550
• Protein ID: WP_011712375.1
• Coordinates: 831684..832253 (-)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: MMC1_RS03555
• Protein ID: WP_041641921.1
• Coordinates: 832255..832695 (-)
• Length: 147 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMC1_RS03530	827233..827826	-	594	WP_011712371.1	electron transport complex subunit RsxA	-
MMC1_RS03535	828345..829418	+	1074	WP_011712372.1	iron-sulfur cluster carrier protein ApbC	-
MMC1_RS03540	829535..830098	-	564	WP_160162654.1	YdcF family protein	-
MMC1_RS03545	830369..831559	+	1191	WP_011712374.1	Na+/H+ antiporter NhaA	-
MMC1_RS03550	831684..832253	-	570	WP_011712375.1	PIN domain-containing protein	Toxin
MMC1_RS03555	832255..832695	-	441	WP_041641921.1	excisionase family DNA-binding protein	Antitoxin
MMC1_RS03560	833020..833211	+	192	Protein_700	Na+/H+ antiporter NhaA	-
MMC1_RS03565	833321..833974	-	654	WP_011712378.1	FkbM family methyltransferase	-
MMC1_RS03570	834109..835314	-	1206	WP_011712379.1	pyridoxal phosphate-dependent aminotransferase	-
MMC1_RS03575	835419..837446	+	2028	WP_011712380.1	excinuclease ABC subunit UvrB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-113)

Antitoxin

• Helix-turn-helix domain, group 17 (76-123)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 21280.42 Da
• Isoelectric Point: 5.2677

>T21774 WP_011712375.1 NC_008576:c832253-831684 [Magnetococcus marinus MC-1]
MATFTAIYDACVLYPAPLRDLLVGLATTGLFRARWTDEIHEEWINNLLINKPHLTREALNRTKELMDAAVADCLVTGYEK
LIPSLTLPDADDRHVLAAAIRSCAEVIVTFNLKDFPSDALNNFGVFAEHPDDFISNLLDLNQKAVIRTVKNQRARLKNPP
ITSQNFIDTLRRQQLTKTAAFLDDAIDFI

Nucleotide

• Length: 570 bp

>T21774 NC_008576:c832253-831684 [Magnetococcus marinus MC-1]
ATGGCTACTTTTACTGCCATATATGACGCCTGTGTATTATACCCCGCCCCTCTTCGGGATTTATTAGTGGGGCTCGCGAC
CACCGGTTTATTCCGGGCAAGGTGGACAGATGAGATCCACGAGGAGTGGATAAATAACCTTCTTATCAATAAGCCGCATC
TGACAAGGGAGGCGCTTAACCGGACCAAAGAGTTAATGGATGCTGCCGTTGCAGACTGCTTGGTAACGGGCTATGAGAAA
TTGATTCCAAGCCTAACACTTCCGGATGCTGACGATCGACATGTCTTAGCTGCTGCGATCAGGTCTTGTGCAGAAGTTAT
TGTAACCTTCAACCTCAAAGACTTTCCGTCAGATGCACTTAATAATTTTGGTGTCTTTGCAGAACATCCCGATGATTTTA
TCAGTAATCTACTCGATTTAAATCAGAAAGCAGTCATTAGAACAGTTAAAAATCAACGGGCTAGGTTGAAAAATCCGCCA
ATCACAAGTCAAAATTTTATTGATACCTTGCGCAGGCAGCAGCTTACAAAAACAGCCGCCTTTCTTGATGATGCAATTGA
TTTTATATAG

Antitoxin

Protein

• Length: 147 a.a.
• Molecular weight: 16429.89 Da
• Isoelectric Point: 5.9998

>AT21774 WP_041641921.1 NC_008576:c832695-832255 [Magnetococcus marinus MC-1]
MMDFFDLPSEQEVDAATNARRQLAAILGKGDHAQLRLVDGEKEITLPFVAIQILAKILDQMAEGHAVSLVPVHAELTTQE
AADFLNVSRPYFVKLLEKNEIAYHKAGVRRRVTFKDLVAYKERIHIKANNALDELAKQAQELDMGY

Nucleotide

• Length: 441 bp

>AT21774 NC_008576:c832695-832255 [Magnetococcus marinus MC-1]
ATGATGGATTTCTTCGATCTTCCCTCAGAACAAGAGGTCGATGCGGCCACCAATGCGAGGCGTCAATTAGCAGCCATACT
TGGTAAGGGTGATCACGCTCAGCTACGCTTGGTGGACGGTGAAAAGGAAATAACCCTTCCATTCGTTGCGATTCAAATAC
TCGCAAAAATTCTTGATCAAATGGCTGAAGGTCATGCGGTTTCATTGGTGCCGGTTCACGCTGAGTTAACCACTCAAGAG
GCCGCCGATTTTCTGAATGTATCACGGCCCTACTTTGTAAAATTGTTAGAGAAAAATGAAATCGCTTACCATAAGGCAGG
TGTTCGTCGCAGAGTTACATTCAAAGATTTGGTTGCGTATAAAGAGCGCATACACATTAAAGCCAATAACGCTTTGGATG
AATTGGCTAAGCAGGCACAGGAACTCGATATGGGGTATTAA