Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 936924..937578 Replicon chromosome
Accession NZ_CP083886
Organism Escherichia coli strain NDM2

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag LCE23_RS05480 Protein ID WP_000244777.1
Coordinates 937171..937578 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag LCE23_RS05475 Protein ID WP_000354046.1
Coordinates 936924..937190 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCE23_RS05450 (932093) 932093..932836 + 744 WP_000951964.1 SDR family oxidoreductase -
LCE23_RS05455 (932893) 932893..934326 - 1434 WP_001446971.1 6-phospho-beta-glucosidase BglA -
LCE23_RS05460 (934371) 934371..934682 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
LCE23_RS05465 (934846) 934846..935505 + 660 WP_000250274.1 hemolysin III family protein -
LCE23_RS05470 (935701) 935701..936681 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
LCE23_RS05475 (936924) 936924..937190 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
LCE23_RS05480 (937171) 937171..937578 + 408 WP_000244777.1 protein YgfX Toxin
LCE23_RS05485 (937618) 937618..938139 - 522 WP_001055874.1 flavodoxin FldB -
LCE23_RS05490 (938251) 938251..939147 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
LCE23_RS05495 (939172) 939172..939882 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LCE23_RS05500 (939888) 939888..941621 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T217725 WP_000244777.1 NZ_CP083886:937171-937578 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T217725 NZ_CP114599:3633321-3633611 [Phenylobacterium sp. NIBR 498073]
ATGGTCCGGTACATCCTGTCGCCCAAGGCGAAGGCCGACCTGAGCGAGATCTGGGACTACGGCGCCGATCACTGGGGCGT
CGATCGGGCCACCGACTACATTCGCGACATCCAGCGCGCGATCGAGCACGCAGCAGCCCATCCGCTCCGCGGCCGCGCAT
GTGACGAGGTTCGAGCCGGCTACTTCAAGGTCTCCGTCGGCTCCCATCTCTTGTTCCATCGGCTAGTCGACGACGTGCTC
GATGTGGTCCGGGTGCTTCACCAAAGGATGGACGTCGGCCGGCATCTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT217725 WP_000354046.1 NZ_CP083886:936924-937190 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT217725 NZ_CP114599:3633080-3633313 [Phenylobacterium sp. NIBR 498073]
ATGGGCAAGAACACCTCCATCAGCCTTGGCGAGCACTTCGCGGCGTTCATCGAGACGGAGGTCGCAAAGGGGCGCTACGC
GTCGGCCAGCGAGGTCGTGCGCGCAAGCCTGCGTCTCCTGGAGGAACGCGAGGCGCAGCTTGAAGCCCTCCGCCTCGCTC
TGATCGAAGGCGAAGAGAGCGGCCCTTCTACACCCTTCGATTTCGACGCGTTCATCGCCTCCAAGCGCGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References