Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 791918..792753 Replicon chromosome
Accession NZ_CP083886
Organism Escherichia coli strain NDM2

Toxin (Protein)


Gene name yeeV Uniprot ID S1EZ92
Locus tag LCE23_RS04795 Protein ID WP_000854726.1
Coordinates 791918..792295 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag LCE23_RS04800 Protein ID WP_064226358.1
Coordinates 792385..792753 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCE23_RS04765 (787326) 787326..788303 + 978 WP_000633209.1 type II secretion system minor pseudopilin GspK -
LCE23_RS04770 (788300) 788300..789478 + 1179 WP_000094991.1 type II secretion system protein GspL -
LCE23_RS04775 (789480) 789480..790016 + 537 WP_000942785.1 GspM family type II secretion system protein YghD -
LCE23_RS04780 (790297) 790297..791139 - 843 WP_077737641.1 DUF4942 domain-containing protein -
LCE23_RS04785 (791224) 791224..791421 - 198 WP_000839269.1 DUF957 domain-containing protein -
LCE23_RS04790 (791433) 791433..791921 - 489 WP_063100845.1 DUF5983 family protein -
LCE23_RS04795 (791918) 791918..792295 - 378 WP_000854726.1 TA system toxin CbtA family protein Toxin
LCE23_RS04800 (792385) 792385..792753 - 369 WP_064226358.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LCE23_RS04805 (792832) 792832..793053 - 222 WP_000692312.1 DUF987 domain-containing protein -
LCE23_RS04810 (793122) 793122..793598 - 477 WP_064226357.1 RadC family protein -
LCE23_RS04815 (793613) 793613..794098 - 486 WP_042631074.1 antirestriction protein -
LCE23_RS04820 (794189) 794189..795007 - 819 WP_077737897.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14164.10 Da        Isoelectric Point: 7.8045

>T217724 WP_000854726.1 NZ_CP083886:c792295-791918 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T217724 NZ_CP114594:63414-63566 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGATTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13652.36 Da        Isoelectric Point: 6.4761

>AT217724 WP_064226358.1 NZ_CP083886:c792753-792385 [Escherichia coli]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPHHQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT217724 NZ_CP114594:c63359-63302 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1EZ92

Antitoxin

Source ID Structure

References