Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 860327..860981 | Replicon | chromosome |
Accession | NZ_CP083880 | ||
Organism | Escherichia coli strain NDM3 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | S1PAM6 |
Locus tag | LCE26_RS04215 | Protein ID | WP_000244781.1 |
Coordinates | 860574..860981 (+) | Length | 136 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | S1PPB1 |
Locus tag | LCE26_RS04210 | Protein ID | WP_000354046.1 |
Coordinates | 860327..860593 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LCE26_RS04190 (856415) | 856415..857848 | - | 1434 | WP_001521235.1 | 6-phospho-beta-glucosidase BglA | - |
LCE26_RS04195 (857893) | 857893..858204 | + | 312 | WP_001182949.1 | N(4)-acetylcytidine aminohydrolase | - |
LCE26_RS04200 (858368) | 858368..859027 | + | 660 | WP_000250269.1 | hemolysin III family protein | - |
LCE26_RS04205 (859104) | 859104..860084 | - | 981 | WP_000886050.1 | tRNA-modifying protein YgfZ | - |
LCE26_RS04210 (860327) | 860327..860593 | + | 267 | WP_000354046.1 | FAD assembly factor SdhE | Antitoxin |
LCE26_RS04215 (860574) | 860574..860981 | + | 408 | WP_000244781.1 | protein YgfX | Toxin |
LCE26_RS04220 (861021) | 861021..861542 | - | 522 | WP_001521233.1 | flavodoxin FldB | - |
LCE26_RS04225 (861654) | 861654..862550 | + | 897 | WP_000806638.1 | site-specific tyrosine recombinase XerD | - |
LCE26_RS04230 (862575) | 862575..863285 | + | 711 | WP_001521231.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
LCE26_RS04235 (863291) | 863291..865024 | + | 1734 | WP_021523238.1 | single-stranded-DNA-specific exonuclease RecJ | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 16061.99 Da Isoelectric Point: 11.5202
>T217686 WP_000244781.1 NZ_CP083880:860574-860981 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR
Download Length: 408 bp
>T217686 NZ_CP114584:1190367-1190627 [Salinivibrio proteolyticus]
ATGAAAATCATTTCGTTTACTGAAGCGAGAAATGGCCTCAAAACGGTATTAGATGGGGTGGTTGATGACGCTGATACCAC
TATCATCACCCGACGTGATGCGGAAGACGCGGTGGTGATGTCGCTTGATTACTACAACAGCCTTATGGAAACCGTTCATC
TGTTGCGCTCACCCGCCAATGCTGAGCACCTAAATCGGTCTATTACTCAGTACAAGATGGGGAAAGCGATGGAGCACGCG
TTAGTCGATAGCGATGAGTAG
ATGAAAATCATTTCGTTTACTGAAGCGAGAAATGGCCTCAAAACGGTATTAGATGGGGTGGTTGATGACGCTGATACCAC
TATCATCACCCGACGTGATGCGGAAGACGCGGTGGTGATGTCGCTTGATTACTACAACAGCCTTATGGAAACCGTTCATC
TGTTGCGCTCACCCGCCAATGCTGAGCACCTAAATCGGTCTATTACTCAGTACAAGATGGGGAAAGCGATGGAGCACGCG
TTAGTCGATAGCGATGAGTAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 10547.12 Da Isoelectric Point: 5.1599
>AT217686 WP_000354046.1 NZ_CP083880:860327-860593 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI
Download Length: 267 bp
>AT217686 NZ_CP114584:1190620-1190883 [Salinivibrio proteolyticus]
ATGAGTAGTCGCTTACTTTGCTGGACGGATGATGCGTGGCGTGACTACGTGTACTGGCAAAGCCAGGATAGAAAAACACT
CAAGCGAATCAACAAGCTCATCCTCGATGTAAAACGAACGCCATTCGAGGGCATAGGTAAGCCCGAAGCACTAAAAGAAA
ACCTGACCGGCTTCTGGTCGCGGCGTATTGATGATACCAATCGGCTGGTTTACGCCGTGGATGATACGTCTATTACGATC
CTATCTTGCCGATATCACTATTAG
ATGAGTAGTCGCTTACTTTGCTGGACGGATGATGCGTGGCGTGACTACGTGTACTGGCAAAGCCAGGATAGAAAAACACT
CAAGCGAATCAACAAGCTCATCCTCGATGTAAAACGAACGCCATTCGAGGGCATAGGTAAGCCCGAAGCACTAAAAGAAA
ACCTGACCGGCTTCTGGTCGCGGCGTATTGATGATACCAATCGGCTGGTTTACGCCGTGGATGATACGTCTATTACGATC
CTATCTTGCCGATATCACTATTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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