217672

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3443472..3444090 Replicon chromosome
Accession NZ_CP083877
Organism Escherichia coli strain NDM4

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LCE22_RS16645 Protein ID WP_001291435.1
Coordinates 3443872..3444090 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LCE22_RS16640 Protein ID WP_000344800.1
Coordinates 3443472..3443846 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCE22_RS16630 (3438561) 3438561..3439754 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LCE22_RS16635 (3439777) 3439777..3442926 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
LCE22_RS16640 (3443472) 3443472..3443846 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LCE22_RS16645 (3443872) 3443872..3444090 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LCE22_RS16650 (3444262) 3444262..3444813 + 552 WP_000102564.1 maltose O-acetyltransferase -
LCE22_RS16655 (3444929) 3444929..3445399 + 471 WP_000136192.1 YlaC family protein -
LCE22_RS16660 (3445563) 3445563..3447113 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LCE22_RS16665 (3447155) 3447155..3447508 - 354 WP_000878140.1 DUF1428 domain-containing protein -
LCE22_RS16675 (3447887) 3447887..3448198 + 312 WP_000409911.1 MGMT family protein -
LCE22_RS16680 (3448229) 3448229..3448801 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T217672 WP_001291435.1 NZ_CP083877:3443872-3444090 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T217672 NZ_CP114571:c2780014-2779911 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT217672 WP_000344800.1 NZ_CP083877:3443472-3443846 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT217672 NZ_CP114571:2779898-2780107 [Enterobacter hormaechei]
TTTTCAAGCAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGC
TAAAAGTTGGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGCA
AAAGTGGTCTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References