Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4124124..4124719 Replicon chromosome
Accession NZ_CP083872
Organism Escherichia coli strain NDM5

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag LCE27_RS19985 Protein ID WP_000239579.1
Coordinates 4124124..4124474 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag LCE27_RS19990 Protein ID WP_001223208.1
Coordinates 4124468..4124719 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCE27_RS19965 (4119570) 4119570..4120592 - 1023 WP_001295197.1 ABC transporter permease -
LCE27_RS19970 (4120606) 4120606..4122108 - 1503 WP_000205784.1 sugar ABC transporter ATP-binding protein -
LCE27_RS19975 (4122248) 4122248..4123204 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LCE27_RS19980 (4123514) 4123514..4124044 + 531 WP_000055072.1 inorganic diphosphatase -
LCE27_RS19985 (4124124) 4124124..4124474 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
LCE27_RS19990 (4124468) 4124468..4124719 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LCE27_RS19995 (4124931) 4124931..4125272 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
LCE27_RS20000 (4125275) 4125275..4129054 - 3780 WP_000060978.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T217647 WP_000239579.1 NZ_CP083872:c4124474-4124124 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T217647 NZ_CP114550:c1410806-1410510 [Xylella fastidiosa subsp. pauca]
ATGCCACGGGTGATCTTCGCTCCCGAAGCCATCCTGAACATTCAACGATTGCGGAATTTCCTGCATCCGAAGAACACCGA
TGCCGCAAGGCGGGCCGGTGAAGCCATCATGCGGGGTGCGCGGATGCTTGGAGCGCAGCCACATATCGGTCGTCCGGTTG
ATGATATGCCCGATGAGTACAGGGAATGGCTGATTGACTTCGGAGATAGCGGTTATGTGGCCCGCTACCACATTGATGGC
GATACCGTCACGATCTTGGCTGTTCGACACCATAAGGAAGTGGGATACACCAGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT217647 WP_001223208.1 NZ_CP083872:c4124719-4124468 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT217647 NZ_CP114550:c1411072-1410794 [Xylella fastidiosa subsp. pauca]
ATGGGCATGGCAACCTCCATCAAGCTTGATGATGAGCTGAAAGGACGTGTGCAGCATCTGGCCGATGTTCGCCGCCGCAC
TTCGCACTGGATCATGCGCGAGGCGATCGCGCAGTACGTTGAGCGTGAGGAAAAGCGTGAGACGTTTCGGCAGGACACGC
TGAAGGCATGGGAAGAGTTTCAGGCGACCGGCCTGCACGTGACGACCGAAGAAGTCGAGAAGTGGCTTTCGAGTTGGGGC
ACTGAAAATGAATTGTCAGCGCCCGTATGCCACGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References