Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3441461..3442079 Replicon chromosome
Accession NZ_CP083869
Organism Escherichia coli strain NDM6

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LCE24_RS17985 Protein ID WP_001291435.1
Coordinates 3441861..3442079 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LCE24_RS17980 Protein ID WP_000344800.1
Coordinates 3441461..3441835 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCE24_RS17970 (3436550) 3436550..3437743 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LCE24_RS17975 (3437766) 3437766..3440915 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
LCE24_RS17980 (3441461) 3441461..3441835 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LCE24_RS17985 (3441861) 3441861..3442079 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LCE24_RS17990 (3442251) 3442251..3442802 + 552 WP_000102564.1 maltose O-acetyltransferase -
LCE24_RS17995 (3442918) 3442918..3443388 + 471 WP_000136192.1 YlaC family protein -
LCE24_RS18000 (3443552) 3443552..3445102 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LCE24_RS18005 (3445144) 3445144..3445497 - 354 WP_000878140.1 DUF1428 domain-containing protein -
LCE24_RS18015 (3445876) 3445876..3446187 + 312 WP_000409911.1 MGMT family protein -
LCE24_RS18020 (3446218) 3446218..3446790 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T217621 WP_001291435.1 NZ_CP083869:3441861-3442079 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T217621 NZ_CP114542:c2880937-2880629 [Brevundimonas subvibrioides]
ATGGCACCTGATACCATTCCGTTCGATCCGGCGCGATATCTGAATGCCCCGGAAGCGATCGAGGAATACCTGGTCGCCTC
GTTCGAGGAGGCGGCCGAGTACGGCGATCCAGGAATCATCACCAAAGCCCTCGGCACGGTCGCCCGCGCCAAGGGCATGA
CGAAGATGGCAGAGGATGCCGAACTATCCCGGACAGCCCTTTACCGTGCGCTCAGCGCCGAGGGTCGTCCCGAACTGGCC
ACCATCTTCAAGGTGATGCAGGCCCTGGGCCTGCGCCTCGCGCCTGTACGCATGAAGCCTGCCGCTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT217621 WP_000344800.1 NZ_CP083869:3441461-3441835 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT217621 NZ_CP114542:c2881253-2880927 [Brevundimonas subvibrioides]
ATGTCGCCCATAGACGACAGTTCTGGCTTCGAGCTCGAGTTCTCGGAGACGTTCGATGCATGGCTTCAAGGGCTCCGTGA
TCACCGCGCTGCCGCGCGTATCACGGTACGGCTTGAAAGACTTGAGCGTGGTCATTGGGGCGACGCCAGGTCTGTCGGCG
AGGGCGTAACGGAGCTGCGTATCGATTATGGCCCCGGCTACCGGCTCTACGCCGCGCGGAGGGGACGACGTATTGTGTTG
ATGCTGGCTGGTGGCGACAAGTCCAGCCAGCGCAGGGACATTGAGGCCGCCAAGGTGCTGGCCAGGGAATATGGCGATGG
CACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References