Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3441461..3442079 | Replicon | chromosome |
Accession | NZ_CP083869 | ||
Organism | Escherichia coli strain NDM6 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | H5UYE2 |
Locus tag | LCE24_RS17985 | Protein ID | WP_001291435.1 |
Coordinates | 3441861..3442079 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | S1PTH5 |
Locus tag | LCE24_RS17980 | Protein ID | WP_000344800.1 |
Coordinates | 3441461..3441835 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LCE24_RS17970 (3436550) | 3436550..3437743 | + | 1194 | WP_001295324.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
LCE24_RS17975 (3437766) | 3437766..3440915 | + | 3150 | WP_001132469.1 | efflux RND transporter permease AcrB | - |
LCE24_RS17980 (3441461) | 3441461..3441835 | + | 375 | WP_000344800.1 | Hha toxicity modulator TomB | Antitoxin |
LCE24_RS17985 (3441861) | 3441861..3442079 | + | 219 | WP_001291435.1 | HHA domain-containing protein | Toxin |
LCE24_RS17990 (3442251) | 3442251..3442802 | + | 552 | WP_000102564.1 | maltose O-acetyltransferase | - |
LCE24_RS17995 (3442918) | 3442918..3443388 | + | 471 | WP_000136192.1 | YlaC family protein | - |
LCE24_RS18000 (3443552) | 3443552..3445102 | + | 1551 | WP_001310610.1 | cyclic-guanylate-specific phosphodiesterase PdeB | - |
LCE24_RS18005 (3445144) | 3445144..3445497 | - | 354 | WP_000878140.1 | DUF1428 domain-containing protein | - |
LCE24_RS18015 (3445876) | 3445876..3446187 | + | 312 | WP_000409911.1 | MGMT family protein | - |
LCE24_RS18020 (3446218) | 3446218..3446790 | - | 573 | WP_000779831.1 | YbaY family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T217621 WP_001291435.1 NZ_CP083869:3441861-3442079 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T217621 NZ_CP114542:c2880937-2880629 [Brevundimonas subvibrioides]
ATGGCACCTGATACCATTCCGTTCGATCCGGCGCGATATCTGAATGCCCCGGAAGCGATCGAGGAATACCTGGTCGCCTC
GTTCGAGGAGGCGGCCGAGTACGGCGATCCAGGAATCATCACCAAAGCCCTCGGCACGGTCGCCCGCGCCAAGGGCATGA
CGAAGATGGCAGAGGATGCCGAACTATCCCGGACAGCCCTTTACCGTGCGCTCAGCGCCGAGGGTCGTCCCGAACTGGCC
ACCATCTTCAAGGTGATGCAGGCCCTGGGCCTGCGCCTCGCGCCTGTACGCATGAAGCCTGCCGCTTGA
ATGGCACCTGATACCATTCCGTTCGATCCGGCGCGATATCTGAATGCCCCGGAAGCGATCGAGGAATACCTGGTCGCCTC
GTTCGAGGAGGCGGCCGAGTACGGCGATCCAGGAATCATCACCAAAGCCCTCGGCACGGTCGCCCGCGCCAAGGGCATGA
CGAAGATGGCAGAGGATGCCGAACTATCCCGGACAGCCCTTTACCGTGCGCTCAGCGCCGAGGGTCGTCCCGAACTGGCC
ACCATCTTCAAGGTGATGCAGGCCCTGGGCCTGCGCCTCGCGCCTGTACGCATGAAGCCTGCCGCTTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14557.39 Da Isoelectric Point: 4.7395
>AT217621 WP_000344800.1 NZ_CP083869:3441461-3441835 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
Download Length: 375 bp
>AT217621 NZ_CP114542:c2881253-2880927 [Brevundimonas subvibrioides]
ATGTCGCCCATAGACGACAGTTCTGGCTTCGAGCTCGAGTTCTCGGAGACGTTCGATGCATGGCTTCAAGGGCTCCGTGA
TCACCGCGCTGCCGCGCGTATCACGGTACGGCTTGAAAGACTTGAGCGTGGTCATTGGGGCGACGCCAGGTCTGTCGGCG
AGGGCGTAACGGAGCTGCGTATCGATTATGGCCCCGGCTACCGGCTCTACGCCGCGCGGAGGGGACGACGTATTGTGTTG
ATGCTGGCTGGTGGCGACAAGTCCAGCCAGCGCAGGGACATTGAGGCCGCCAAGGTGCTGGCCAGGGAATATGGCGATGG
CACCTGA
ATGTCGCCCATAGACGACAGTTCTGGCTTCGAGCTCGAGTTCTCGGAGACGTTCGATGCATGGCTTCAAGGGCTCCGTGA
TCACCGCGCTGCCGCGCGTATCACGGTACGGCTTGAAAGACTTGAGCGTGGTCATTGGGGCGACGCCAGGTCTGTCGGCG
AGGGCGTAACGGAGCTGCGTATCGATTATGGCCCCGGCTACCGGCTCTACGCCGCGCGGAGGGGACGACGTATTGTGTTG
ATGCTGGCTGGTGGCGACAAGTCCAGCCAGCGCAGGGACATTGAGGCCGCCAAGGTGCTGGCCAGGGAATATGGCGATGG
CACCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 2MW2 | |
PDB | 1JW2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QBQ5 |