Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 191880..192406 | Replicon | plasmid p11743_1 |
| Accession | NZ_CP083863 | ||
| Organism | Enterobacter kobei strain 11743-yvys | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | LCD49_RS25970 | Protein ID | WP_000323025.1 |
| Coordinates | 191880..192167 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | LCD49_RS25975 | Protein ID | WP_000534858.1 |
| Coordinates | 192167..192406 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LCD49_RS25935 (LCD49_25990) | 187450..187626 | - | 177 | WP_001371930.1 | hypothetical protein | - |
| LCD49_RS25940 (LCD49_25995) | 188137..189081 | + | 945 | WP_000778029.1 | DUF5417 domain-containing protein | - |
| LCD49_RS25945 (LCD49_26000) | 189177..189779 | + | 603 | WP_012695474.1 | hypothetical protein | - |
| LCD49_RS25950 (LCD49_26005) | 189839..190189 | + | 351 | WP_000743059.1 | hypothetical protein | - |
| LCD49_RS25955 (LCD49_26010) | 190236..190439 | + | 204 | WP_001015183.1 | hypothetical protein | - |
| LCD49_RS25960 (LCD49_26015) | 190721..191041 | + | 321 | WP_000332796.1 | hypothetical protein | - |
| LCD49_RS25965 (LCD49_26020) | 191654..191779 | - | 126 | WP_229020258.1 | DUF5431 family protein | - |
| LCD49_RS25970 (LCD49_26030) | 191880..192167 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| LCD49_RS25975 (LCD49_26035) | 192167..192406 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| LCD49_RS25980 (LCD49_26040) | 192431..192535 | + | 105 | Protein_207 | protein YdfV | - |
| LCD49_RS25985 (LCD49_26045) | 192669..193592 | - | 924 | WP_000167917.1 | cation diffusion facilitator family transporter | - |
| LCD49_RS25990 (LCD49_26050) | 193792..194364 | - | 573 | WP_001515348.1 | cytochrome b/b6 domain-containing protein | - |
| LCD49_RS25995 (LCD49_26055) | 194840..196078 | - | 1239 | WP_000219087.1 | IS110-like element ISEsa2 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaTEM-1B / dfrA19 / aph(6)-Id / mcr-9 / tet(D) / blaSHV-12 / sul1 / qacE / aadA17 / catB3 / ARR-3 / blaSIM-1 | - | 1..276053 | 276053 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T217599 WP_000323025.1 NZ_CP083863:c192167-191880 [Enterobacter kobei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T217599 NZ_CP114508:19081-19332 [Ligilactobacillus salivarius]
ATGAATAAGAATTGGTCTGATGAAGCCTGGGATGACTACATGAGCTGGCAAAGTGATAAAAGAATAGTTAAGAAAATTAA
TAAGCTAATAAAAGATATTGATAGACATCCTTTTTCAGGAATAGGTAAACCAGAACCGTTAAAATATGGTTTATCAGGAA
CATGGTCTAGAAGAATTACGGAAGAGCATCGAATAGTCTATGAGATAAAAGATGATGAGATACGTATCTATTCTGTCAGA
GACCATTATTAG
ATGAATAAGAATTGGTCTGATGAAGCCTGGGATGACTACATGAGCTGGCAAAGTGATAAAAGAATAGTTAAGAAAATTAA
TAAGCTAATAAAAGATATTGATAGACATCCTTTTTCAGGAATAGGTAAACCAGAACCGTTAAAATATGGTTTATCAGGAA
CATGGTCTAGAAGAATTACGGAAGAGCATCGAATAGTCTATGAGATAAAAGATGATGAGATACGTATCTATTCTGTCAGA
GACCATTATTAG
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT217599 WP_000534858.1 NZ_CP083863:c192406-192167 [Enterobacter kobei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT217599 NZ_CP114508:18822-19088 [Ligilactobacillus salivarius]
ATGGAAGCTACAACATACTCTAATTTTAGAAAATCCCTTAAATCATTCATGAAACAAGTCAATGAAGATTCAGAACCTTT
AATTGTTACTAATAAAAATAAAGAAGAAGATATTGTTGTTATGGGTAAAGATGACTATGATTCGCTAGTCGAAACCATGA
GAATTATAGAAAATAAATATCTCTATAACAAGATAAGACGTGGCAGAGAACAATTAGATTCTAAAAGTAACTACCACGAT
TTAATCGAGGTTGATGGCGATGAATAA
ATGGAAGCTACAACATACTCTAATTTTAGAAAATCCCTTAAATCATTCATGAAACAAGTCAATGAAGATTCAGAACCTTT
AATTGTTACTAATAAAAATAAAGAAGAAGATATTGTTGTTATGGGTAAAGATGACTATGATTCGCTAGTCGAAACCATGA
GAATTATAGAAAATAAATATCTCTATAACAAGATAAGACGTGGCAGAGAACAATTAGATTCTAAAAGTAACTACCACGAT
TTAATCGAGGTTGATGGCGATGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|