Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4299262..4300048 Replicon chromosome
Accession NZ_CP083862
Organism Enterobacter kobei strain 11743-yvys

Toxin (Protein)


Gene name yeeV Uniprot ID R8WN26
Locus tag LCD49_RS20885 Protein ID WP_016154457.1
Coordinates 4299671..4300048 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A242VSK1
Locus tag LCD49_RS20880 Protein ID WP_009652436.1
Coordinates 4299262..4299621 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD49_RS20820 (LCD49_20865) 4294353..4294619 + 267 WP_009652486.1 hypothetical protein -
LCD49_RS20825 (LCD49_20870) 4294632..4294943 + 312 WP_009652410.1 hypothetical protein -
LCD49_RS20830 (LCD49_20875) 4294990..4295460 + 471 WP_009652431.1 hypothetical protein -
LCD49_RS20835 (LCD49_20880) 4295509..4296021 + 513 WP_009652395.1 DUF4234 domain-containing protein -
LCD49_RS20840 (LCD49_20885) 4296104..4296325 + 222 WP_009652443.1 hypothetical protein -
LCD49_RS20845 (LCD49_20890) 4296381..4296614 + 234 WP_009652474.1 DUF905 domain-containing protein -
LCD49_RS20850 (LCD49_20895) 4296718..4297536 + 819 WP_009652424.1 DUF932 domain-containing protein -
LCD49_RS20855 (LCD49_20900) 4297536..4297790 + 255 WP_009652519.1 hypothetical protein -
LCD49_RS20860 (LCD49_20905) 4297807..4298280 + 474 WP_009652453.1 antirestriction protein -
LCD49_RS20865 (LCD49_20910) 4298291..4298509 + 219 WP_009652503.1 hypothetical protein -
LCD49_RS20870 (LCD49_20915) 4298521..4299003 + 483 WP_016154455.1 DNA repair protein RadC -
LCD49_RS20875 (LCD49_20920) 4299017..4299238 + 222 WP_009652392.1 DUF987 domain-containing protein -
LCD49_RS20880 (LCD49_20925) 4299262..4299621 + 360 WP_009652436.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LCD49_RS20885 (LCD49_20930) 4299671..4300048 + 378 WP_016154457.1 TA system toxin CbtA family protein Toxin
LCD49_RS20890 (LCD49_20935) 4300045..4300536 + 492 WP_009652438.1 DUF5983 family protein -
LCD49_RS20895 (LCD49_20940) 4300566..4300769 + 204 WP_009652505.1 DUF957 domain-containing protein -
LCD49_RS20900 (LCD49_20945) 4300850..4301695 + 846 Protein_4097 DUF4942 domain-containing protein -
LCD49_RS20905 (LCD49_20950) 4301707..4301943 + 237 WP_016154458.1 hypothetical protein -
LCD49_RS20910 (LCD49_20955) 4301990..4302517 - 528 WP_045134821.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14168.19 Da        Isoelectric Point: 9.5224

>T217597 WP_016154457.1 NZ_CP083862:4299671-4300048 [Enterobacter kobei]
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP

Download         Length: 378 bp

>T217597 NZ_CP114406:c2784730-2783993 [Bacillus thuringiensis serovar tenebrionis]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCGTTC
ATTTTAACGCCTAATATTTCAGAAATATGGGGTGCGAAATTTAGCGATATTGGCAAGACAGTTCAATCAATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACCACAATTATTCAAAATGTTAATCCAGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAAGAATATACAAAGAGCTTAAATGTATTTTTAGATTCATATGGGGAAAAAATTGGCGCGAAAATT
GTTGTTTTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCAGTGCAAGTAGAAAATGTCGGGATCATACCAGCAAAAATAGTAAGTGATG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13286.19 Da        Isoelectric Point: 6.4780

>AT217597 WP_009652436.1 NZ_CP083862:4299262-4299621 [Enterobacter kobei]
MSNTIPPVNHDIAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELN
PRHQHCVTLYAKGLICEADSLGSHGYVYLAIYPTPATTE

Download         Length: 360 bp

>AT217597 NZ_CP114406:c2783880-2783752 [Bacillus thuringiensis serovar tenebrionis]
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGATAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATGC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8WN26

Antitoxin

Source ID Structure
AlphaFold DB A0A242VSK1

References