Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3895544..3896222 Replicon chromosome
Accession NZ_CP083862
Organism Enterobacter kobei strain 11743-yvys

Toxin (Protein)


Gene name yeeV Uniprot ID A0A9K1QZI5
Locus tag LCD49_RS18940 Protein ID WP_032949840.1
Coordinates 3895899..3896222 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A9K1QZR3
Locus tag LCD49_RS18935 Protein ID WP_032642918.1
Coordinates 3895544..3895867 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD49_RS18905 (LCD49_18940) 3891722..3891991 + 270 WP_009653703.1 metal-sensing transcriptional repressor -
LCD49_RS18910 (LCD49_18945) 3892004..3893146 + 1143 WP_029602872.1 nickel/cobalt efflux protein RcnA -
LCD49_RS18915 (LCD49_18950) 3893307..3893747 + 441 WP_135695985.1 NirD/YgiW/YdeI family stress tolerance protein -
LCD49_RS18920 (LCD49_18955) 3893968..3894789 + 822 WP_032642912.1 DUF932 domain-containing protein -
LCD49_RS18925 (LCD49_18960) 3894822..3895292 + 471 WP_032642914.1 DNA repair protein RadC -
LCD49_RS18930 (LCD49_18965) 3895301..3895522 + 222 WP_032642916.1 DUF987 domain-containing protein -
LCD49_RS18935 (LCD49_18970) 3895544..3895867 + 324 WP_032642918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LCD49_RS18940 (LCD49_18975) 3895899..3896222 + 324 WP_032949840.1 TA system toxin CbtA family protein Toxin
LCD49_RS18945 (LCD49_18980) 3896977..3897333 + 357 WP_014884928.1 hypothetical protein -
LCD49_RS18950 (LCD49_18985) 3897438..3897998 + 561 WP_032635751.1 YceI family protein -
LCD49_RS18955 (LCD49_18990) 3897990..3898781 - 792 WP_014884930.1 membrane protein -
LCD49_RS18960 (LCD49_18995) 3898778..3899308 - 531 WP_045281725.1 sigma-70 family RNA polymerase sigma factor -
LCD49_RS18965 (LCD49_19000) 3899316..3899843 - 528 WP_045281724.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(12-106)

Antitoxin

Antitoxin CbeA

(4-102)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12143.94 Da        Isoelectric Point: 6.0673

>T217595 WP_032949840.1 NZ_CP083862:3895899-3896222 [Enterobacter kobei]
MQISSVPATVPVSSRLSPVMVWQQLLTYLLEHHYGLTLNDTPFHDDTAIEEHIDAGITLADAVNFLVEKYELARIDRKGF
TWREQPPFITATDILRAKKNIGLLPRS

Download         Length: 324 bp

>T217595 NZ_CP114399:c2784634-2783897 [Bacillus thuringiensis serovar tenebrionis]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCGTTC
ATTTTAACGCCTAATATTTCAGAAATATGGGGTGCGAAATTTAGCGATATTGGCAAGACAGTTCAATCAATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACCACAATTATTCAAAATGTTAATCCAGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAAGAATATACAAAGAGCTTAAATGTATTTTTAGATTCATATGGGGAAAAAATTGGCGCGAAAATT
GTTGTTTTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCAGTGCAAGTAGAAAATGTCGGGATCATACCAGCAAAAATAGTAAGTGATG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12082.82 Da        Isoelectric Point: 6.6250

>AT217595 WP_032642918.1 NZ_CP083862:3895544-3895867 [Enterobacter kobei]
MQNSWGLKRDISPCFGARLVQEGCRLHFLADRAGISGTFNEEEALRLDQAFPLVMKQLELMLTTGELNPRHQHCVTLYHN
GLTCEADTLGSHGYVYIVIYPQAFATR

Download         Length: 324 bp

>AT217595 NZ_CP114399:c2783784-2783656 [Bacillus thuringiensis serovar tenebrionis]
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGATAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATGC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References